Li Hong-Xing, Dong Mei, Peng Xiao-Xiao, Liu Yi-Zhe, Wang Han, Li Chao, Du Yi-Yi, Zhang Kai, Zong Qiang
Department of Neurosurgery, Shengli Oilfield Central Hospital, Dongying, Shandong, China.
Department of Stomatology, Dongying District People's Hospital, Dongying, Shandong, China.
Front Neurol. 2023 Feb 20;14:1103164. doi: 10.3389/fneur.2023.1103164. eCollection 2023.
Although Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by parkin RBR E3 ubiquitin protein ligase () mutations.
In this study, we report the case of a 30-year-old Chinese woman who was affected by -associated YOPD and was treated with levodopa/benserazide during pregnancy. She gave birth to a healthy baby boy with an Apgar score of 9 through an uncomplicated vaginal delivery.
This case further suggests that levodopa/benserazide during pregnancy is safe in the treatment of -associated YOPD.
尽管帕金森病（PD）是第二常见的神经退行性疾病，但PD患者怀孕相对少见，因为PD最常见的发病年龄超出育龄期，帕金森蛋白RBR E3泛素蛋白连接酶（）突变所致的青年型帕金森病（YOPD）患者除外。
在本研究中，我们报告了一名30岁中国女性的病例，她患有与相关的YOPD，孕期接受左旋多巴/苄丝肼治疗。她通过无并发症的阴道分娩产下一名健康男婴，阿氏评分9分。
该病例进一步表明，孕期使用左旋多巴/苄丝肼治疗与相关的YOPD是安全的。
