Adeviye Erşahin Aynur, Acet Mustafa, Erşahin Suat Süphan, Dokuzeylül Güngör Nur
Department of Obstetrics and Gynecology, Bahçesehir University Faculty of Medicine, İstanbul, Turkey.
Department of Obstetrics and Gynecology, Medipol University Faculty of Medicine, İstanbul, Turkey.
J Turk Ger Gynecol Assoc. 2017 Mar 15;18(1):38-42. doi: 10.4274/jtgga.2016.0186.
To investigate whether serum levels of estradiol affect reproductive outcomes of normoresponder women undergoing fresh embryo transfer (ET) versus frozen-thawed ET (FET).
Two hundred fifty-five normoresponder women underwent fresh ET in their first or second in vitro fertilization cycle. Ninety-two women with negative pregnacy test results underwent FET. Clinical and ongoing pregnancy rates, implantation, and live birth rates of women undergoing fresh ET versus FET were compared.
One hundred forty-seven (57.65%) out of the 255 normoresponder women receiving FET had positive beta-human chorionic gonadotrophin (hCG) results. The remaining 108 women had negative beta-hCG results. The clinical pregnancy rates of the fresh ET group were found as 55.69% (n=142). Ninety-two of the 108 women with failed pregnancies underwent FET; 72.83% had positive beta-hCG results (n=67), and 70.65% had clinical pregnancy (n=65). Both biochemical and clinical pregnancy rates of women undergoing FET increased significantly (p<0.012 and p<0.013, respectively). Ongoing pregnancy (60.87% vs. 52.94%) and live birth rates (59.87% vs. 48.63%) were similar in both fresh and FET groups. Serum E2 levels of women who failed to conceive were significantly higher than those women did conceive. Serum progesterone levels of women who conceived versus those that did not were similar.
The detrimental effect of high serum estradiol levels on endometrial receptivity could be prevented by FET.
探讨血清雌二醇水平是否会影响进行新鲜胚胎移植（ET）与冻融胚胎移植（FET）的反应正常女性的生殖结局。
255名反应正常的女性在其第一次或第二次体外受精周期接受新鲜胚胎移植。92名妊娠试验结果为阴性的女性接受冻融胚胎移植。比较接受新鲜胚胎移植与冻融胚胎移植女性的临床妊娠率、持续妊娠率、着床率和活产率。
255名接受冻融胚胎移植的反应正常女性中，147名（57.65%）β-人绒毛膜促性腺激素（hCG）结果为阳性。其余108名女性β-hCG结果为阴性。新鲜胚胎移植组的临床妊娠率为55.69%（n = 142）。108名妊娠失败的女性中有92名接受了冻融胚胎移植；72.83%的女性β-hCG结果为阳性（n = 67），70.65%的女性临床妊娠（n = 65）。接受冻融胚胎移植女性的生化妊娠率和临床妊娠率均显著升高（分别为p < 0.012和p < 0.013）。新鲜胚胎移植组和冻融胚胎移植组的持续妊娠率（60.87%对52.94%）和活产率（59.87%对48.63%）相似。未受孕女性的血清雌二醇水平显著高于受孕女性。受孕女性与未受孕女性的血清孕酮水平相似。
冻融胚胎移植可预防高血清雌二醇水平对子宫内膜容受性的有害影响。
