从一种硅氧烷-水凝胶混合材料中控制释放plectasin NZ2114以抑制金黄色葡萄球菌生物膜
Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm.
作者信息
Klein Kasper, Grønnemose Rasmus Birkholm, Alm Martin, Brinch Karoline Sidelmann, Kolmos Hans Jørn, Andersen Thomas Emil
机构信息
Research Unit of Clinical Microbiology, University of Southern Denmark and Odense University Hospital, Odense, Denmark.
Biomodics ApS, Taastrup, Denmark.
出版信息
Antimicrob Agents Chemother. 2017 Jun 27;61(7). doi: 10.1128/AAC.00604-17. Print 2017 Jul.
Abstract
is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with plectasin derivate NZ2114 in an attempt to design an biofilm-resistant catheter. The material demonstrated promising antibiofilm properties, including properties against methicillin-resistant , thus suggesting a novel application of this antimicrobial peptide.
摘要
是导管相关感染中的主要人类病原体。用互穿聚合物网络修饰导管材料是一种新型材料技术，可实现药物浸渍及后续的控释。在此，我们评估了将该系统与plectasin衍生物NZ2114相结合的潜力，试图设计一种抗生物膜导管。该材料表现出有前景的抗生物膜特性，包括对耐甲氧西林菌的抗性，因此表明了这种抗菌肽的一种新应用。
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