CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, Victoria 3168, Australia; Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia.
Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria 3800, Australia.
Trends Biotechnol. 2014 Feb;32(2):82-90. doi: 10.1016/j.tibtech.2013.09.008. Epub 2013 Oct 28.
In order to colonize abiotic surfaces, bacteria and fungi undergo a profound change in their biology to form biofilms: communities of microbes embedded into a matrix of secreted macromolecules. Despite strict hygiene standards, biofilm-related infections associated with implantable devices remain a common complication in the clinic. Here, the application of highly dosed antibiotics is problematic in that the biofilm (i) provides a protective environment for microbes to evade antibiotics and/or (ii) can provide selective pressure for the evolution of antibiotic-resistant microbes. However, recent research suggests that effective prevention of biofilm formation may be achieved by multifunctional surface coatings that provide both non-adhesive and antimicrobial properties imparted by antimicrobial peptides. Such coatings are the subject of this review.
为了在非生物表面定殖，细菌和真菌在生物学上发生了深刻的变化，形成了生物膜：微生物群落嵌入到分泌的大分子基质中。尽管有严格的卫生标准，但与植入式设备相关的生物膜感染仍然是临床中的常见并发症。在这里，高剂量抗生素的应用存在问题，因为生物膜 (i) 为微生物提供了逃避抗生素的保护环境和/或 (ii) 可以为抗生素耐药微生物的进化提供选择性压力。然而，最近的研究表明，通过多功能表面涂层可以有效地防止生物膜的形成，这些涂层具有抗菌肽赋予的非粘附性和抗菌性能。本文综述了此类涂层。
