Rowland N E, Fregly M J
Center for Neurobiological Sciences, University of Florida, Gainesville 32611.
Behav Neurosci. 1988 Dec;102(6):953-60. doi: 10.1037//0735-7044.102.6.953.
Two experiments were performed with Sprague-Dawley rats to study the effects of different inhibitors of angiotensin I converting enzyme (ACE) on water intake and sodium appetite. Subcutaneous administration of low doses of either enalapril (MK421) or ramipril (Hoe498), like captopril, was dipsogenic. Acute administration of ramipril also enhanced the drinking response to peripherally administered angiotensin I (Ang I). Higher doses inhibited the drinking response to Ang I, administered acutely either peripherally or centrally. These data provide behavioral evidence that the nonsulfhydryl inhibitors enalapril and ramipril inhibit brain converting enzyme activity and that they are considerably more potent than captopril. All three of these compounds, administered chronically in food, induced an appetite for sodium chloride (NaCl) solution. Enalapril and ramipril were more potent than captopril. Plasma renin activity was increased by each of these inhibitors, but the magnitude of the increase was not clearly related to the amount of NaCl consumed. The water intake in response to acute administration of either Ang I or isoproterenol was not reliably increased in rats treated chronically with these inhibitors.
用斯普拉格-道利大鼠进行了两项实验，以研究血管紧张素I转换酶（ACE）的不同抑制剂对水摄入和钠食欲的影响。皮下注射低剂量的依那普利（MK421）或雷米普利（Hoe498），与卡托普利一样，具有致渴作用。急性给予雷米普利还增强了对外周给予的血管紧张素I（Ang I）的饮水反应。更高剂量抑制了对外周或中枢急性给予的Ang I的饮水反应。这些数据提供了行为学证据，表明非巯基抑制剂依那普利和雷米普利抑制脑转换酶活性，且它们比卡托普利的效力更强。这三种化合物长期添加到食物中给予时，均诱导对氯化钠（NaCl）溶液的食欲。依那普利和雷米普利比卡托普利的效力更强。这些抑制剂均使血浆肾素活性增加，但增加的幅度与消耗的NaCl量没有明显关系。用这些抑制剂长期治疗的大鼠，对急性给予Ang I或异丙肾上腺素的饮水反应没有可靠增加。
