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Regadenoson stress during low-level exercise: The EXERRT trial-does it move the needle?

作者信息

Mahmarian John J

机构信息

Houston Methodist DeBakey Heart & Vascular Center, 6550 Fannin Street, Suite 677, Houston, TX, 77030-2717, USA.

出版信息

J Nucl Cardiol. 2017 Jun;24(3):803-808. doi: 10.1007/s12350-017-0873-4. Epub 2017 May 15.

DOI:10.1007/s12350-017-0873-4
PMID:28508268
Abstract
摘要

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Regadenoson stress during low-level exercise: The EXERRT trial-does it move the needle?低强度运动期间的雷加得松负荷试验:EXERRT试验——它有作用吗?
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2
The EXERRT trial: "EXErcise to Regadenoson in Recovery Trial": A phase 3b, open-label, parallel group, randomized, multicenter study to assess regadenoson administration following an inadequate exercise stress test as compared to regadenoson without exercise for myocardial perfusion imaging using a SPECT protocol.EXERRT试验:“恢复试验中使用瑞加诺生的运动试验”:一项3b期、开放标签、平行组、随机、多中心研究,旨在评估在运动负荷试验不充分后给予瑞加诺生与不进行运动直接给予瑞加诺生相比,对使用单光子发射计算机断层扫描(SPECT)协议进行心肌灌注成像的效果。
J Nucl Cardiol. 2017 Jun;24(3):788-802. doi: 10.1007/s12350-017-0813-3. Epub 2017 Feb 21.
3
Lessons from regadenoson and low-level treadmill/regadenoson myocardial perfusion imaging: initial clinical experience in 1263 patients.瑞加德松和低水平跑步机/瑞加德松心肌灌注成像的经验教训:1263 例患者的初步临床经验。
J Nucl Cardiol. 2010 Oct;17(5):853-7. doi: 10.1007/s12350-010-9229-z. Epub 2010 Apr 23.
4
Comparison of hemodynamic and stress testing variables in patients undergoing regadenoson stress myocardial perfusion imaging to regadenoson with adjunctive low-level exercise myocardial perfusion imaging.比较瑞加德松应激心肌灌注成像和瑞加德松联合低水平运动心肌灌注成像患者的血流动力学和应激试验变量。
J Nucl Cardiol. 2013 Jun;20(3):336-43; quiz 344-5. doi: 10.1007/s12350-012-9671-1. Epub 2013 Feb 21.
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A useful and easy to develop combined stress test for myocardial perfusion imaging: Regadenoson and isometric exercise, preliminary results.一种用于心肌灌注成像的实用且易于开展的联合负荷试验:雷加曲班与等长运动,初步结果
J Nucl Cardiol. 2017 Feb;24(1):34-40. doi: 10.1007/s12350-015-0278-1. Epub 2015 Nov 5.
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Considerations when measuring myocardial perfusion reserve by cardiovascular magnetic resonance using regadenoson.考虑使用雷卡地诺生测量心血管磁共振心肌灌注储备时的注意事项。
J Cardiovasc Magn Reson. 2012 Dec 28;14(1):89. doi: 10.1186/1532-429X-14-89.
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Influence of body mass index and type of low-level exercise on the side effect profile of regadenoson.体重指数和低水平运动类型对雷卡地松副作用特征的影响。
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The prognostic value of regadenoson SPECT myocardial perfusion imaging in patients with end-stage renal disease.雷加曲塞单光子发射计算机断层扫描心肌灌注成像在终末期肾病患者中的预后价值。
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引用本文的文献

1
Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation.单光子发射计算机断层扫描(SPECT)心肌灌注成像指南:仪器设备、采集、处理与解读
J Nucl Cardiol. 2018 Oct;25(5):1784-1846. doi: 10.1007/s12350-018-1283-y.
2
Review of cardiovascular imaging in the Journal of Nuclear Cardiology in 2017. Part 2 of 2: Myocardial perfusion imaging.2017 年《核医学杂志》心血管成像述评。第 2 部分,共 2 部分:心肌灌注成像。
J Nucl Cardiol. 2018 Aug;25(4):1390-1399. doi: 10.1007/s12350-018-1266-z. Epub 2018 Apr 16.
3
Safer stress tests for myocardial perfusion imaging.

本文引用的文献

1
Optimizing Evaluation of Patients with Low-to-Intermediate-Risk Acute Chest Pain: A Randomized Study Comparing Stress Myocardial Perfusion Tomography Incorporating Stress-Only Imaging Versus Cardiac CT.优化低至中度风险急性胸痛患者的评估:一项比较仅采用负荷成像的负荷心肌灌注断层扫描与心脏CT的随机研究。
J Nucl Med. 2016 Mar;57(3):378-84. doi: 10.2967/jnumed.115.166595. Epub 2015 Dec 3.
2
Regadenoson provides perfusion results comparable to adenosine in heterogeneous patient populations: a quantitative analysis from the ADVANCE MPI trials.在异质性患者群体中,雷加曲班提供的灌注结果与腺苷相当:来自ADVANCE MPI试验的定量分析。
J Nucl Cardiol. 2015 Apr;22(2):248-61. doi: 10.1007/s12350-014-9981-6. Epub 2014 Oct 7.
3
用于心肌灌注成像的更安全的负荷试验。
J Nucl Cardiol. 2019 Apr;26(2):629-632. doi: 10.1007/s12350-017-1083-9. Epub 2017 Oct 16.
Reduction in occupational and patient radiation exposure from myocardial perfusion imaging: impact of stress-only imaging and high-efficiency SPECT camera technology.
减少心肌灌注成像中的职业和患者辐射暴露:仅压力成像和高效 SPECT 相机技术的影响。
J Nucl Med. 2013 Aug;54(8):1251-7. doi: 10.2967/jnumed.112.112680. Epub 2013 May 30.
4
Temporal trends in the frequency of inducible myocardial ischemia during cardiac stress testing: 1991 to 2009.心脏负荷试验中可诱导性心肌缺血的频率的时间趋势:1991 年至 2009 年。
J Am Coll Cardiol. 2013 Mar 12;61(10):1054-65. doi: 10.1016/j.jacc.2012.11.056.
5
Safety and feasibility of adjunctive regadenoson injection at peak exercise during exercise myocardial perfusion imaging: The Both Exercise and Regadenoson Stress Test (BERST) trial.在运动心肌灌注成像中运动峰值时辅助使用瑞加德松注射的安全性和可行性:运动和瑞加德松应激试验(BERST)试验。
J Nucl Cardiol. 2013 Apr;20(2):197-204. doi: 10.1007/s12350-013-9679-1. Epub 2013 Feb 13.
6
Regadenoson pharmacologic stress for myocardial perfusion imaging: a three-way comparison between regadenoson administered at peak exercise, during walk recovery, or no-exercise.瑞加德松在心肌灌注成像中的药物负荷作用:瑞加德松在运动峰值时、运动恢复期或无运动时给药的三种比较。
J Nucl Cardiol. 2013 Apr;20(2):214-21; quiz 222-6. doi: 10.1007/s12350-012-9660-4. Epub 2012 Dec 12.
7
Safety and tolerability of regadenoson in 514 SPECT MPI patients with and without coronary artery disease and submaximal exercise heart rate response.在有和无冠状动脉疾病以及次最大运动心率反应的 514 例 SPECT MPI 患者中,瑞加德松的安全性和耐受性。
Eur J Nucl Med Mol Imaging. 2013 Feb;40(3):341-8. doi: 10.1007/s00259-012-2296-4. Epub 2012 Dec 4.
8
A strategy of symptom-limited exercise with regadenoson-as-needed for stress myocardial perfusion imaging: a randomized controlled trial.症状限制运动加按需瑞加德松应激心肌灌注成像策略:一项随机对照试验。
J Nucl Cardiol. 2013 Apr;20(2):185-96. doi: 10.1007/s12350-012-9641-7. Epub 2012 Nov 28.
9
Safety and feasibility of regadenoson use for suboptimal heart rate response during symptom-limited standard Bruce exercise stress test.在症状限制标准 Bruce 运动压力测试中,因心率反应不理想而使用雷卡地诺松的安全性和可行性。
J Nucl Cardiol. 2012 Oct;19(5):970-8. doi: 10.1007/s12350-012-9562-5. Epub 2012 May 8.
10
A randomized, double-blind, placebo-controlled study assessing the safety and tolerability of regadenoson in subjects with asthma or chronic obstructive pulmonary disease.一项评估雷卡地森在哮喘或慢性阻塞性肺疾病受试者中的安全性和耐受性的随机、双盲、安慰剂对照研究。
J Nucl Cardiol. 2012 Aug;19(4):681-92. doi: 10.1007/s12350-012-9547-4. Epub 2012 Apr 7.