瞬时受体电位通道与帕金森病
TRPC Channels and Parkinson's Disease.
作者信息
Sukumaran Pramod, Sun Yuyang, Schaar Anne, Selvaraj Senthil, Singh Brij B
机构信息
Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, 58201, USA.
出版信息
Adv Exp Med Biol. 2017;976:85-94. doi: 10.1007/978-94-024-1088-4_8.
Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified that could lead to Parkinson's disease; however, almost all of them are directly or indirectly dependent on Ca signaling. Importantly, though disturbances in Ca homeostasis have been implicated in Parkinson's disease and other neuronal diseases, the identity of the calcium channel remains elusive. Members of the transient receptor potential canonical (TRPC) channel family have been identified as a new class of Ca channels, and it could be anticipated that these channels could play important roles in neurodegenerative diseases, especially in PD. Thus, in this chapter we have entirely focused on TRPC channels and elucidated its role in PD.
摘要
帕金森病（PD）是一种常见的神经退行性疾病，它涉及黑质致密部（SNpc）区域中多巴胺能神经元的退化。已经确定了许多可能导致帕金森病的因素；然而，几乎所有这些因素都直接或间接地依赖于钙信号传导。重要的是，尽管钙稳态紊乱与帕金森病和其他神经疾病有关，但钙通道的身份仍然难以捉摸。瞬时受体电位香草酸（TRPC）通道家族的成员已被确定为一类新的钙通道，可以预期这些通道可能在神经退行性疾病中发挥重要作用，尤其是在帕金森病中。因此，在本章中，我们完全聚焦于TRPC通道，并阐明了其在帕金森病中的作用。
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