Rubinek Tami, Wolf Ido, Modan-Moses Dalit
Institute of Oncology, Sourasky Medical Center, Tel Aviv, Israel.
Institute of Oncology, Sourasky Medical Center, Tel Aviv, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pediatr Endocrinol Rev. 2016 Sep;14(1):9-18. doi: 10.17458/PER.2016.RWM.LongevityHormoneKlotho.
Klotho was first discovered as an aging-suppressor gene. Mice that do not express klotho die prematurely with multiple symptoms of aging, several of which are also characteristic of decreased GH/IGF-1 axis activity. Klotho is highly expressed in the brain, the kidney, and parathyroid and pituitary glands, but can also serve as a circulating hormone by its shedding, forming soluble klotho (sKlotho) that can be detected in blood, cerebrospinal fluid and urine. Several lines of evidence suggest an association between klotho levels and activity of the GH/IHG-1 axis: The GH-secreting cells in the anterior pituitary of klotho-deficient mice are hypotrophic; klotho levels are altered in subjects with pathologies of the GH/IGF-1 axis; and accumulating data indicate that klotho is a direct regulator of GH secretion. Thus, klotho seems to be a new player in the intricate regulation of the GH/IGF-1 axis.
klotho最初被发现是一种衰老抑制基因。不表达klotho的小鼠会过早死亡，并出现多种衰老症状，其中一些也是生长激素/胰岛素样生长因子-1（GH/IGF-1）轴活性降低的特征。klotho在大脑、肾脏、甲状旁腺和垂体中高度表达，但它也可以通过脱落成为一种循环激素，形成可溶性klotho（sKlotho），可在血液、脑脊液和尿液中检测到。有几条证据表明klotho水平与GH/IGF-1轴的活性之间存在关联：klotho基因缺陷小鼠垂体前叶分泌生长激素的细胞发育不良；GH/IGF-1轴病变患者的klotho水平发生改变；越来越多的数据表明klotho是生长激素分泌的直接调节因子。因此，klotho似乎是GH/IGF-1轴复杂调节中的一个新角色。
Zotero 插件