Hegde Shruti S, Bijol Vanesa, Jaber Bertrand L
Division of Nephrology, Department of Medicine, St. Elizabeth's Medical Center, 736 Cambridge Street, Boston, MA, 02135, USA.
Department of Medicine, Tufts University School of Medicine, Boston, MA, USA.
CEN Case Rep. 2016 Nov;5(2):188-191. doi: 10.1007/s13730-016-0222-5. Epub 2016 Jun 7.
Drug-induced pauci-immune crescentic glomerulonephritis has been described with several agents, including propylthiouracil, minocycline, D-penicillamine, and hydralazine. We present the case of a 60-year-old man who presented with rapidly progressive glomerulonephritis in the setting of recent use of trimethoprim-sulfamethoxazole complicated by the development of the Stevens-Johnson syndrome, and was found to have biopsy-proven pauci-immune crescentic glomerulonephritis and undetectable anti-neutrophilic cytoplasmic antibodies. We review the existing literature on the potential association between sulfonamides and hypersensitivity polyangiitis.
药物性寡免疫性新月体性肾小球肾炎已被描述与多种药物有关，包括丙硫氧嘧啶、米诺环素、D-青霉胺和肼屈嗪。我们报告一例60岁男性患者，该患者近期使用甲氧苄啶-磺胺甲恶唑后出现快速进展性肾小球肾炎，并并发史蒂文斯-约翰逊综合征，经活检证实为寡免疫性新月体性肾小球肾炎且抗中性粒细胞胞浆抗体检测不到。我们回顾了关于磺胺类药物与超敏性血管炎之间潜在关联的现有文献。
