Minz Ranjana W, Chhabra Seema, Joshi Kusum, Rani Lekha, Sharma Nidhi, Sakhuja Vinay, Duggal Rajan, Pasricha Neelam
Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Pathol Microbiol. 2012 Jan-Mar;55(1):28-32. doi: 10.4103/0377-4929.94850.
The need to perform reporting of renal biopsies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides in a more uniform manner required relook at our eight-year data.
To document detailed renal histopathology of pauci-immune rapidly progressive glomerulonephritis (RPGN) and also to seek any significant differences in renal histology of C-ANCA-positive, P-ANCA-positive, and ANCA-negative patients.
A detailed analysis of the histopathologic features of renal biopsies of 48 patients in whom a diagnosis of pauci-immune glomerulonephritis was concluded on renal biopsy and who presented clinically as rapidly progressive renal failure was done.
One-way ANOVA and Pearson Chi square tests.
Compared with ANCA +ve patients, the ANCA -ve patients were much younger (46.85 ± 16.12 years vs 34.28±15.94 years). No significant differences were found between renal lesions of C-ANCA, P-ANCA, and ANCA-negative patients, except for diffuse tubular atrophy which was more severe and more frequently present with P-ANCA positivity (P value=0.013).
Pauci-immune RPGN (irrespective of ANCA status) is a relatively rare disorder in patients who are undergoing the renal biopsy at our institute, constituting 2% of all renal biopsies submitted. It is mandatory to have ANCA serology status during reporting of a kidney biopsy showing pauci-immune crescentic or necrotizing glomerulonephritis. Also, if a uniform reporting strategy is followed throughout the country, the studies from this vast country will be comparable.
需要以更统一的方式报告抗中性粒细胞胞浆抗体（ANCA）相关血管炎的肾活检情况，这就要求重新审视我们八年的数据。
记录寡免疫性急进性肾小球肾炎（RPGN）的详细肾脏组织病理学特征，并寻找C-ANCA阳性、P-ANCA阳性和ANCA阴性患者肾脏组织学上的任何显著差异。
对48例经肾活检诊断为寡免疫性肾小球肾炎且临床上表现为急进性肾衰竭的患者的肾活检组织病理学特征进行了详细分析。
单因素方差分析和Pearson卡方检验。
与ANCA阳性患者相比，ANCA阴性患者年龄小得多（46.85±16.12岁对34.28±15.94岁）。C-ANCA、P-ANCA和ANCA阴性患者的肾脏病变之间未发现显著差异，但弥漫性肾小管萎缩在P-ANCA阳性时更严重且更常见（P值=0.013）。
寡免疫性RPGN（无论ANCA状态如何）在我院接受肾活检的患者中是一种相对罕见的疾病，占所有送检肾活检的2%。在报告显示寡免疫性新月体性或坏死性肾小球肾炎的肾活检时，必须有ANCA血清学状态。此外，如果在全国范围内采用统一的报告策略，来自这个幅员辽阔国家的研究将具有可比性。
