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一名维持性血液透析患者因严重高磷血症导致急性肿瘤性钙化症。

Acute tumoral calcinosis due to severe hyperphosphatemia in a maintenance hemodialysis patient.

作者信息

Nishime Keizo, Takahashi Hiroki

机构信息

Division of Nephrology, Department of Internal Medicine, Rakuwakai Otowakinen Hospital, 29-1 Koyamachinjyucho, Yamashina, Kyoto, 607-8116, Japan.

Division of Nephrology, Department of Internal Medicine, Saiseikai Shigaken Hospital, 2-4-1 Ohashi, Rittou, Shiga, 520-3046, Japan.

出版信息

CEN Case Rep. 2016 Nov;5(2):203-208. doi: 10.1007/s13730-016-0225-2. Epub 2016 Jun 24.

Abstract

We report the case of a maintenance hemodialysis patient with severe hyperphosphatemia (26.6 mg/dL) who developed acute tumoral calcinosis. The patient started receiving maintenance hemodialysis after being diagnosed with type 2 diabetes mellitus. The patient's phosphate levels suddenly increased. He had not taken the prescribed phosphate binders for the past 5 years. He noticed swelling of the palmar aspects of his right thumb, which was diagnosed as tumoral calcinosis. His serum phosphate level reached 26.6 mg/dL. He started taking medication to lower his serum phosphate levels. The patient had a long history of eating convenience foods. As food additives in convenience foods could be a major source of phosphate, the patient corrected this habit by replacing convenience foods with special foods for dialysis patients. His symptoms improved along with the decrease in his serum phosphate levels. The main reason for the abrupt decrease in phosphate levels could be the correction of his dietary habits. Therefore, phosphate levels in processed foods should be carefully considered in dialysis patients.

摘要

我们报告了一例维持性血液透析患者,该患者患有严重高磷血症(26.6mg/dL)并发生了急性肿瘤性钙化。该患者在被诊断为2型糖尿病后开始接受维持性血液透析。患者的磷酸盐水平突然升高。在过去5年里,他一直未服用规定的磷酸盐结合剂。他注意到右手拇指掌侧肿胀,被诊断为肿瘤性钙化。他的血清磷酸盐水平达到了26.6mg/dL。他开始服用降低血清磷酸盐水平的药物。该患者长期有食用方便食品的习惯。由于方便食品中的食品添加剂可能是磷酸盐的主要来源,患者通过用透析患者专用食品替代方便食品来纠正这一习惯。随着血清磷酸盐水平的下降,他的症状有所改善。磷酸盐水平突然下降的主要原因可能是饮食习惯的纠正。因此,对于透析患者,应仔细考虑加工食品中的磷酸盐含量。

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The phosphate binder equivalent dose.磷结合剂等效剂量。
Semin Dial. 2011 Jan-Feb;24(1):41-9. doi: 10.1111/j.1525-139X.2011.00849.x.
8
The emerging role of phosphate in vascular calcification.磷酸盐在血管钙化中的新作用。
Kidney Int. 2009 May;75(9):890-7. doi: 10.1038/ki.2008.644. Epub 2009 Jan 14.

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