一名急性髓系白血病合并意义未明单克隆丙种球蛋白病患者的轻链型范科尼综合征
Light chain Fanconi syndrome in a patient with acute myeloid leukemia and monoclonal gammopathy of undetermined significance.
作者信息
Ross Daniel W, Wanchoo Rimda, Guigova Adriana, Ghiuzeli Cristina, Allen Steven L, Jhaveri Kenar D
机构信息
Division of Kidney Diseases and Hypertension, Department of Medicine, Hofstra Northwell School of Medicine, 450 Lakeville Road, Lake Success, NY, 11042, USA.
Division of Hematology, Department of Medicine, Hofstra Northwell School of Medicine, 450 Lakeville Road, Lake Success, NY, 11042, USA.
出版信息
CEN Case Rep. 2016 Nov;5(2):238-241. doi: 10.1007/s13730-016-0232-3. Epub 2016 Aug 30.
Proximal tubules are a target for paraproteinemic diseases. Cast nephropathy, light chain deposition diseases, and amyloidosis are frequently encountered in patients with multiple myeloma. Rarely, a subset of patients develop light chain Fanconi syndrome (LCFS). LCFS has been reported with multiple myeloma, monoclonal gammopathy of renal significance (MGRS), chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia and diffuse large B-cell lymphoma. No cases have been described with other hematologic malignancies. We report the first case of lambda LCFS in a patient with both acute myeloid leukemia (AML) and monoclonal gammopathy of undetermined significance (MGUS).
近端肾小管是副蛋白血症性疾病的一个靶器官。管型肾病、轻链沉积病和淀粉样变性在多发性骨髓瘤患者中很常见。很少有患者会发展为轻链型范科尼综合征（LCFS）。已有报道称，LCFS与多发性骨髓瘤、具有肾意义的单克隆丙种球蛋白病（MGRS）、慢性淋巴细胞白血病、华氏巨球蛋白血症和弥漫性大B细胞淋巴瘤有关。尚未有其他血液系统恶性肿瘤相关病例的描述。我们报告了首例同时患有急性髓系白血病（AML）和意义未明的单克隆丙种球蛋白病（MGUS）的患者发生λ型LCFS的病例。
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