Anzai Michiko, Kenmochi Takashi, Kitamura Hiroshi, Kurayama Hideaki, Takiguchi Yuichi, Matsumura Chieko, Kanemoto Katsuyoshi
Department of Pediatrics, Chiba-East National Hospital, National Hospital Organization, 673 Nitona-cho, Chuo, Chiba, Chiba, 260-8712, Japan.
Department of Surgery, Chiba-East National Hospital, National Hospital Organization, Chiba, Japan.
CEN Case Rep. 2012 Nov;1(2):90-95. doi: 10.1007/s13730-012-0020-7. Epub 2012 Jun 6.
Recipients of organ transplantation on immunosuppressive medications are at increased risk for developing de novo malignancies, including skin cancer, Kaposi's sarcoma, in situ carcinomas of the uterine cervix, anogenital cancers, renal cell carcinoma, and post-transplant lymphoproliferative disorders (PTLD). However, there are few case reports of germ cell tumors after organ transplantation. There are some case reports of testicular seminoma, but not mediastinal seminoma. This case report is the first description of a mediastinal seminoma that developed de novo 28 months after renal transplantation and that was initially diagnosed as PTLD. To improve outcomes of organ transplant recipients, it is important to report rare cases of malignancies arising while on immunosuppressive medications. When we detect mediastinal tumor arising after organ transplantation while on immunosuppressive therapy, diseases other than PTLD should be considered in the differential diagnosis.
接受免疫抑制药物治疗的器官移植受者发生新发恶性肿瘤的风险增加，包括皮肤癌、卡波西肉瘤、子宫颈原位癌、肛门生殖器癌、肾细胞癌以及移植后淋巴细胞增殖性疾病（PTLD）。然而，器官移植后发生生殖细胞肿瘤的病例报告很少。有一些睾丸精原细胞瘤的病例报告，但没有纵隔精原细胞瘤的报告。本病例报告首次描述了1例肾移植28个月后新发的纵隔精原细胞瘤，该肿瘤最初被诊断为PTLD。为改善器官移植受者的治疗效果，报告免疫抑制药物治疗期间发生的罕见恶性肿瘤病例很重要。当我们在免疫抑制治疗期间检测到器官移植后出现纵隔肿瘤时，鉴别诊断应考虑PTLD以外的疾病。
