依达拉奉、利尿剂和非甾体抗炎药联合使用导致一名老年慢性肾脏病患者发生急性肾损伤。
The combined use of edaravone, diuretics, and nonsteroidal anti-inflammatory drugs caused acute kidney injury in an elderly patient with chronic kidney disease.
作者信息
Liu Guang Jian, Wang Yun Fu, Zeng Yan Jun, Ding Li, Luo Guo Jun, Zhang Li Ping, Zhang Jian'e
机构信息
Department of Neurology, Taihe Hospital Affiliated to Hubei University of Medicine, People's South Road No. 32, Shiyan, 442000, Hubei, China.
Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing, 100022, China.
出版信息
CEN Case Rep. 2012 Nov;1(2):96-103. doi: 10.1007/s13730-012-0022-5. Epub 2012 Jun 8.
The purpose of this study was to draw attention to the fact that the combined use of edaravone, diuretics, and nonsteroidal anti-inflammatory drugs (NSAIDs) may lead to acute kidney injury. This study was a case report of acute kidney injury resulting from the combined use of the aforementioned types of drugs. A 77-year-old male patient with chronic kidney disease (third stage) who was treated with a combination of edaravone, diuretics, and NSAIDs showed significantly increased blood urea nitrogen and creatinine. Interestingly, the blood urea nitrogen and creatinine levels returned to pretreatment levels after the medications were stopped. The patient's score on the Naranjo Adverse Drug Reaction Probability Scale was a nine, and the score on the Drug Interaction Probability Scale was a five. For elderly patients with chronic kidney disease, the combined use of edaravone, diuretics, and NSAIDs should be avoided.
本研究的目的是提醒人们注意依达拉奉、利尿剂和非甾体抗炎药（NSAIDs）联合使用可能导致急性肾损伤这一事实。本研究是一例因联合使用上述类型药物导致急性肾损伤的病例报告。一名77岁患有慢性肾脏病（第三期）的男性患者，在接受依达拉奉、利尿剂和NSAIDs联合治疗后，血尿素氮和肌酐显著升高。有趣的是，停药后血尿素氮和肌酐水平恢复到治疗前水平。该患者在Naranjo药物不良反应概率量表上的评分为9分，在药物相互作用概率量表上的评分为5分。对于老年慢性肾脏病患者，应避免联合使用依达拉奉、利尿剂和NSAIDs。
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