School of Instrument Science and Opto-Electronics Engineering, Hefei University of Technology, Hefei 230009, China.
Institute of Biomedical Technologies, Auckland University of Technology, Auckland 1142, New Zealand.
Sensors (Basel). 2017 May 16;17(5):1139. doi: 10.3390/s17051139.
Eucapnic voluntary hyperpnoea (EVH) challenge provides objective criteria for exercise-induced asthma (EIA) or exercise-induced bronchoconstriction (EIB), and it was recommended to justify the use of inhaled β₂-agonists by athletes for the Olympics. This paper presents the development of a compact and easy-to-use EVH apparatus for assessing EIB in human subjects. The compact apparatus has been validated on human subjects and the results have been compared to the conventional EVH system. Twenty-two swimmers, including eleven healthy subjects and eleven subjects who had been physician-diagnosed with asthma, were recruited from sport and recreation centers throughout Auckland, New Zealand. Each subject performed two EVH challenge tests using the proposed breathing apparatus and the conventional Phillips EVH apparatus on separate days, respectively. Forced expiratory volume in one second (FEV₁) was measured before and after the challenges. A reduction in FEV₁ of 10% or more was considered positive. Of the eleven subjects who were previously diagnosed with asthma, EIB was present in all subjects (100%) in the compact EVH group, while it was presented in ten subjects (90.91%) in the conventional EVH challenge group. Of the eleven healthy subjects, EIB was present in one subject (4.55%) in the compact EVH group, while it was not present in the conventional EVH group. Experimental results showed that the compact EVH system has potential to become an alternative tool for EIB detection.
通气过度激发试验（EVH）为运动性哮喘（EIA）或运动性支气管收缩（EIB）提供了客观的诊断标准，并建议将其作为运动员参加奥运会时使用吸入性β₂-受体激动剂的正当理由。本文介绍了一种用于评估人体 EIB 的紧凑型、易于使用的 EVH 设备的开发。该紧凑型设备已在人体上进行了验证，并将结果与传统的 EVH 系统进行了比较。22 名游泳运动员，包括 11 名健康受试者和 11 名经医生诊断为哮喘的受试者，从新西兰奥克兰的运动和娱乐中心招募。每位受试者分别使用提出的呼吸设备和传统的 Phillips EVH 设备进行两次 EVH 挑战测试。在挑战前后测量一秒钟用力呼气量（FEV₁）。FEV₁降低 10%或更多被认为是阳性。在之前被诊断为哮喘的 11 名受试者中，在紧凑型 EVH 组中，所有受试者（100%）均出现 EIB，而在传统 EVH 挑战组中，有 10 名受试者（90.91%）出现 EIB。在 11 名健康受试者中，在紧凑型 EVH 组中，有 1 名受试者（4.55%）出现 EIB，而在传统 EVH 组中则未出现。实验结果表明，紧凑型 EVH 系统有可能成为检测 EIB 的替代工具。
