Sani Marc-Antoine, Separovic Frances, Gehman John D
School of Chemistry, Bio21 Institute, University of Melbourne, Melbourne, VIC, 3010, Australia.
Biophys Rev. 2012 Dec;4(4):283-290. doi: 10.1007/s12551-012-0071-1. Epub 2012 Mar 24.
Natural cell membranes are composed of a remarkable variety of lipids, which provide specific biophysical properties to support membrane protein function. An improved understanding of this complexity of membrane composition may also allow the design of membrane active drugs. Crafting a relevant model of a cell membrane with controlled composition is becoming an art, with the ability to reveal the molecular mechanisms of biological processes and lead to better treatment of pathologies. By matching physiological observations from in vivo experiments to high-resolution information, more easily obtained from in vitro studies, complex interactions at the lipid interface are determined. The role of the lipid network in biological membranes is, therefore, the subject of increasing attention.
天然细胞膜由种类繁多的脂质组成，这些脂质提供特定的生物物理特性以支持膜蛋白的功能。对膜成分这种复杂性的深入理解也可能有助于设计膜活性药物。构建具有可控成分的相关细胞膜模型正成为一门艺术，它能够揭示生物过程的分子机制并带来更好的疾病治疗方法。通过将体内实验的生理学观察结果与更容易从体外研究中获得的高分辨率信息相匹配，可以确定脂质界面处的复杂相互作用。因此，脂质网络在生物膜中的作用越来越受到关注。
