[The state of membrane structures of heart cells during ischemia].

Under conditions of perfusion of isolated rabbit heart in aerobic medium and, especially, during ischemia, cytochrome c was liberated from heart cells into perfusate, thus indicating that integrity of mitochondrial outer membrane and of cell membrane was impaired. In situ developed deficiency of cytochrome c was distinctly less as compared with isolated mitochondria (50%, 3 hrs perfusion in ischemia), which appears to occur in response to ultrastructural impairments of mitochondria arising during their isolation and to other reasons.