葡萄糖转运蛋白1在牙源性角化囊肿、含牙囊肿和成釉细胞瘤中的表达：一项免疫组织化学研究。
Glucose Transporter 1 Expression in Odontogenic Keratocyst, Dentigerous Cyst, and Ameloblastoma: An Immunohistochemical Study.
作者信息
Bandyopadhyay Alokenath, Panda Abikshyeet, Behura Shyam S, Ramachandra Sujatha, Dash Kailash C, Mishra Pallavi
机构信息
Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology University, Bhubaneswar, Odisha, India.
Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology University, Bhubaneswar, Odisha, India, Phone: +919040324224, e-mail:
出版信息
J Contemp Dent Pract. 2017 May 1;18(5):366-370. doi: 10.5005/jp-journals-10024-2048.
INTRODUCTION
An array of odontogenic lesions manifest in the maxillofacial region with variable presentations. The biological behavior of lesions, such as odontogenic keratocyst (OKC), dentigerous cyst (DC), and ameloblastoma (AM) always invite debate. Glucose transporter 1 (GLUT-1) is proven to be an indicator of metabolic behavior of several benign and malignant neoplasms.
AIM
The purpose of this study was to evaluate the expression of GLUT-1 in OKC, DC, and AM to understand their metabolic behavior.
MATERIALS AND METHODS
Immunohistochemical expression of GLUT-1 was evaluated in each of the 15 cases of OKC, DC, and AM. The number of labeled cells, staining intensity, and membrane or cytoplasmic expressions were the parameters assessed and analyzed using chi-square test.
RESULTS
All cases showed positive GLUT-1 expression: 86.6% OKC showed more than 50% labeled cells followed by DC (40%) and AM (26.5%); 53.3% OKC showed strong intensity in comparison to AM, which showed weak intensity in 53.3% cases; 86.6% of OKCs showed both membrane and cytoplasmic expression followed by DC (40%) and AM (26.6%), whereas 73.3% of AM showed only membrane expression followed by DC (60%) and OKC (13.3%).
CONCLUSION
Odontogenic keratocyst was found out to be more metabolically active followed by DC and AM.
引言
一系列牙源性病变在颌面部表现出不同的症状。牙源性角化囊肿（OKC）、含牙囊肿（DC）和成釉细胞瘤（AM）等病变的生物学行为一直存在争议。葡萄糖转运蛋白1（GLUT-1）已被证明是几种良性和恶性肿瘤代谢行为的指标。
目的
本研究旨在评估GLUT-1在OKC、DC和AM中的表达，以了解它们的代谢行为。
材料与方法
对15例OKC、DC和AM病例分别进行GLUT-1的免疫组织化学表达评估。标记细胞数量、染色强度以及膜或细胞质表达是评估参数，并使用卡方检验进行分析。
结果
所有病例均显示GLUT-1阳性表达：86.6%的OKC显示超过50%的标记细胞，其次是DC（40%）和AM（26.5%）；53.3%的OKC显示强染色强度，而AM在53.3%的病例中显示弱染色强度；86.6%的OKC显示膜和细胞质表达，其次是DC（40%）和AM（26.6%），而73.3%的AM仅显示膜表达，其次是DC（60%）和OKC（13.3%）。
结论
发现牙源性角化囊肿的代谢活性更高，其次是DC和AM。
Zotero 插件