McMurran Mary, Day Florence, Reilly Joseph, Delport Juan, McCrone Paul, Whitham Diane, Tan Wei, Duggan Conor, Montgomery Alan A, Williams Hywel C, Adams Clive E, Jin Huajie, Moran Paul, Crawford Mike J
Institute of Mental Health, University of Nottingham, Nottingham, UK.
Nottingham Clinical Trials Unit, University of Nottingham.
J Pers Disord. 2017 Dec;31(6):810-826. doi: 10.1521/pedi_2017_31_286. Epub 2017 May 17.
We compared psychoeducation and problem solving (PEPS) therapy against usual treatment in a multisite randomized-controlled trial. The primary outcome was social functioning. We aimed to recruit 444 community-dwelling adults with personality disorder; however, safety concerns led to an early cessation of recruitment. A total of 154 people were randomized to PEPS and 152 to usual treatment. Follow-up at 72 weeks was completed for 68%. PEPS therapy was no more effective than usual treatment for improving social functioning (adjusted difference in mean Social Functioning Questionnaire scores = -0.73; 95% CI [-1.83, 0.38]; p = 0.19). PEPS therapy is not an effective treatment for improving social functioning of adults with personality disorder living in the community.
在一项多中心随机对照试验中，我们将心理教育与问题解决（PEPS）疗法与常规治疗进行了比较。主要结局是社会功能。我们的目标是招募444名患有 personality disorder 的社区成年居民；然而，出于安全考虑，招募提前终止。共有154人被随机分配接受PEPS治疗，152人接受常规治疗。72周时68%的人完成了随访。在改善社会功能方面，PEPS疗法并不比常规治疗更有效（社会功能问卷平均得分的调整差异=-0.73；95%置信区间[-1.83, 0.38]；p=0.19）。PEPS疗法并非改善社区中患有 personality disorder 的成年人社会功能的有效治疗方法。
