Tiligada E, Wilson J F
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Cardiff, U.K.
Brain Res. 1988 Aug 9;457(2):379-82. doi: 10.1016/0006-8993(88)90711-1.
The dopamine agonist apomorphine (10(-6) M) significantly reduced the 50 mM K+-stimulated, Ca2+-dependent release of immunoreactive alpha-melanocyte-stimulating hormone (alpha-MSH) from superfused slices of rat hypothalamus but did not alter baseline peptide release. Flupenthixol (10(-6) M), a dopamine receptor antagonist, significantly increased both basal and 50 mM K+-stimulated alpha-MSH release, possibly via blockade of inhibition caused by endogenous dopamine release. The latter increases were Ca2+-dependent and were inhibited by 10(-6) M apomorphine.
多巴胺激动剂阿扑吗啡（10⁻⁶ M）显著降低了50 mM钾离子刺激下大鼠下丘脑灌流切片中免疫反应性α-黑素细胞刺激素（α-MSH）的钙离子依赖性释放，但未改变基础肽释放。氟哌噻吨（10⁻⁶ M），一种多巴胺受体拮抗剂，显著增加了基础和50 mM钾离子刺激下的α-MSH释放，可能是通过阻断内源性多巴胺释放引起的抑制作用。后者的增加是钙离子依赖性的，并被10⁻⁶ M阿扑吗啡所抑制。
