碘水平与甲状腺乳头状癌之间的关系：一项系统评价和荟萃分析。
Relationship between iodine levels and papillary thyroid carcinoma: A systematic review and meta-analysis.
作者信息
Lee Joon-Hyop, Hwang Yunji, Song Ra-Yeong, Yi Jin Wook, Yu Hyeong Won, Kim Su-Jin, Chai Young Jun, Choi June Young, Lee Kyu Eun, Park Sue K
机构信息
Department of Surgery, Seoul National University Bundang Hospital, 300 Gumi-dong Bundang-gu, Seongnam-si, Gyeonggi-do, Korea.
Thyroid and Endocrine Surgery Section, Department of Surgery, Gachon University Gil Medical Center, Incheon, Republic of Korea.
出版信息
Head Neck. 2017 Aug;39(8):1711-1718. doi: 10.1002/hed.24797. Epub 2017 May 17.
BACKGROUND
Iodine excess has been suggested as an exogenous risk factor of papillary thyroid cancer (PTC). We performed a systematic review and meta-analysis to assess the relationship between iodine exposure measured in various forms and PTC prevalence.
METHODS
We searched MEDLINE, Embase, and the Cochrane Library for case-control studies on iodine and PTC published up to December 2015. Exposure to iodine was compared between PTC and control groups.
RESULTS
From the 16 selected studies, the odds ratio (OR) for the overall effect size between high iodine exposure and PTC risk was 1.418 (95% confidence interval [CI] 1.054-1.909). Based on 7 studies conducted in high iodinated regions, a positive association between iodine exposure and PTC was observed (OR 2.200; 95% CI 1.389-3.483).
CONCLUSION
This study demonstrated a higher exposure to iodine in patients with PTC compared with controls, especially for patients from high iodinated regions.
背景
碘过量已被认为是甲状腺乳头状癌（PTC）的一个外源性风险因素。我们进行了一项系统评价和荟萃分析，以评估以各种形式测量的碘暴露与PTC患病率之间的关系。
方法
我们检索了MEDLINE、Embase和Cochrane图书馆，查找截至2015年12月发表的关于碘与PTC的病例对照研究。比较了PTC组和对照组的碘暴露情况。
结果
从16项选定的研究中，高碘暴露与PTC风险之间总体效应大小的比值比（OR）为1.418（95%置信区间[CI]1.054 - 1.909）。基于在高碘地区进行的7项研究，观察到碘暴露与PTC之间存在正相关（OR 2.200；95% CI 1.389 - 3.483）。
结论
本研究表明，与对照组相比，PTC患者的碘暴露量更高，尤其是来自高碘地区的患者。
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