Wu Yuan-Hung, Wang Lei-Chi, Yen Sang-Hue, Yu Wei-Kuang, Kao Shu-Ching, Kau Hui-Chuan, Tsai Chieh-Chih, Liu Catherine Jui-Ling
1 Department of Oncology, Taipei Veterans General Hospital, National Yang-Ming University , Taipei, Taiwan .
2 Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University , Taipei, Taiwan .
J Ocul Pharmacol Ther. 2017 Sep;33(7):543-548. doi: 10.1089/jop.2016.0175. Epub 2017 May 17.
To investigate the change of serum IgG4 concentrations correlated with clinical evolution in patients with ocular adnexal marginal zone B cell lymphoma associated with IgG4-related ophthalmic disease (IgG4-ROD).
Three consecutive patients with histopathologically confirmed ocular adnexal marginal zone B cell lymphoma associated with IgG4-ROD were evaluated. Two patients received radiotherapy and 1 patient received steroid therapy. Treatment outcome was evaluated by clinical symptoms, radiologic examination, and change of serum IgG4 level in these patients.
All patients had elevated serum IgG4 before treatment (462, 338, and 780 mg/dL respectively.) The 2 patients who received radiotherapy achieved complete remission and the serum IgG4 decreased to 345 and 92 mg/dL, respectively. The patient who underwent systemic steroid achieved partial remission and the serum IgG4 decrease to 161 mg/dL.
Our study showed elevated serum IgG4 in all patients with ocular adnexal marginal zone B cell lymphoma associated with IgG4-ROD. In addition, the elevated serum IgG4 may decrease or keep stable after treatment, accompanied by improvement in clinical symptoms and reduction of lesions.
探讨与IgG4相关眼病（IgG4-ROD）相关的眼附属器边缘区B细胞淋巴瘤患者血清IgG4浓度变化与临床病情演变的相关性。
对3例经组织病理学确诊的与IgG4-ROD相关的眼附属器边缘区B细胞淋巴瘤患者进行评估。2例患者接受了放疗，1例患者接受了类固醇治疗。通过临床症状、影像学检查以及这些患者血清IgG4水平的变化来评估治疗效果。
所有患者治疗前血清IgG4均升高（分别为462、338和780mg/dL）。接受放疗的2例患者达到完全缓解，血清IgG4分别降至345和92mg/dL。接受全身类固醇治疗的患者达到部分缓解，血清IgG4降至161mg/dL。
我们的研究表明，所有与IgG4-ROD相关的眼附属器边缘区B细胞淋巴瘤患者血清IgG4均升高。此外，治疗后血清IgG4升高可能会降低或保持稳定，同时临床症状改善，病变减少。
