Mühlhäusser Julia, Winkler Jörg, Babst Reto, Beeres Frank J P
Department of Traumatology and Orthopedic Surgery, Kantonsspital Luzern, Switzerland.
Medicine (Baltimore). 2017 May;96(20):e6948. doi: 10.1097/MD.0000000000006948.
The treatment after open and infected fractures with extensive soft tissue damage and bone deficit remains a challenging clinical problem. The technique described by Masquelet, using a temporary cement spacer to induce a membrane combined with reconstructive soft tissue coverage, is a possible solution. This study describes the work-up, operative procedure, complications, and the outcome of a homogenous group of patients with an open and infected tibia fracture and segmental bone loss treated with the Masquelet technique (MT).This retrospective study evaluates patients having sustained an open tibia fracture treated with the MT between 2008 and 2013 with a follow up of at least 1 year. The defect was either primary, caused by a high-grade open fracture or secondary due to a non-union after an open fracture. Prerequisite conditions prior to the procedure of the Masquelet were a defect zone with eradicated infection, an intact soft tissue cover and stability provided by an external fixation.Volume of the defect, time until the implantation of the spacer, time of the spacer in situ and the time to clinical and radiological union were evaluated. Patient records were screened for reoperations and complications. The functional clinical outcome was measured.Eight patients were treated with a follow up over 1 year. The spacer was implanted after a median of 11 (2-70) weeks after the accident. The predefined conditions for the Masquelet phase were reached after a median of 12 (7-34) operations.Seven patients required reconstructive soft tissue coverage. The volume of the defect had a median of 111 (53.9-621.6) cm, the spacer was in situ for a median of 12 (7-26) weeks. Radiological healing was achieved in 7 cases after a median time of 52 (26-93) weeks.Full weight bearing was achieved after a median time of 16 (11-24) weeks. Four patients needed a reoperation. The lower limb functional index was a median of 60% (32-92%).Seven out of 8 patients treated in this group of severe open and infected tibia fractures did both clinically and radiologically heal. Due to the massive destruction of the soft tissue, patients needed several reoperations with soft tissue debridements and reconstruction before the spacer and the bone graft could be implanted.
对于伴有广泛软组织损伤和骨缺损的开放性感染性骨折,其治疗仍然是一个具有挑战性的临床问题。Masquelet描述的技术,即使用临时骨水泥间隔物诱导形成一层膜并结合重建性软组织覆盖,是一种可能的解决方案。本研究描述了一组采用Masquelet技术(MT)治疗的开放性感染性胫骨骨折并伴有节段性骨缺损患者的检查、手术过程、并发症及治疗结果。这项回顾性研究评估了2008年至2013年间接受MT治疗的开放性胫骨骨折患者,随访时间至少为1年。骨缺损要么是由高能量开放性骨折导致的原发性缺损,要么是开放性骨折后骨不连引起的继发性缺损。在进行Masquelet手术之前的先决条件是缺损区域感染已根除、软组织覆盖完整且由外固定提供稳定性。评估了缺损的体积、间隔物植入前的时间、间隔物在位的时间以及临床和影像学愈合的时间。筛查患者记录中的再次手术情况和并发症。测量功能临床结果。8例患者接受了超过1年的随访。间隔物在事故发生后的中位时间为11(2 - 70)周后植入。在进行了中位次数为12(7 - 34)次手术后达到了Masquelet阶段的预定条件。7例患者需要进行重建性软组织覆盖。缺损体积的中位数为111(53.9 - 621.6)cm³,间隔物在位的中位时间为12(7 - 26)周。7例患者在中位时间为52(26 - 93)周后实现了影像学愈合。在中位时间为16(11 - 24)周后实现了完全负重。4例患者需要再次手术。下肢功能指数的中位数为60%(32 - 92%)。在这组严重开放性感染性胫骨骨折患者中,8例患者中有7例在临床和影像学上均实现了愈合。由于软组织的大量破坏,患者在植入间隔物和骨移植之前需要进行多次包括软组织清创和重建的再次手术。