Matsumoto R R, Walker J M
Walter S. Hunter Laboratory of Psychology, Brown University, Providence, RI 02912.
Eur J Pharmacol. 1988 Dec 6;158(1-2):161-5. doi: 10.1016/0014-2999(88)90268-3.
1,3-Di-ortho-tolylguanidine (DTG), a compound with marked selectivity for sigma receptors was iontophoretically applied to neurons in the red nucleus and nearby mesencephalic reticular formation. Spontaneous firing of rubral neurons was reduced by DTG in most cases. However, in the reticular formation, less than half of the cells tested showed inhibition; the remaining cells showed either an increase in rate or no consistent response to DTG. This corresponds to the greater density of sigma receptors in the red nucleus and supports previous work which suggests that sigma receptors play a role in the regulation of movement and posture.
1,3-二邻甲苯基胍（DTG）是一种对σ受体具有显著选择性的化合物，通过离子电泳法施加于红核及附近中脑网状结构的神经元。在大多数情况下，DTG可降低红核神经元的自发放电。然而，在网状结构中，不到一半的受试细胞表现出抑制作用；其余细胞要么放电频率增加，要么对DTG无一致反应。这与红核中σ受体密度较高相一致，并支持了先前的研究工作，即σ受体在运动和姿势调节中发挥作用。
