血清多不饱和脂肪酸代谢产物作为筛查结直肠癌潜在生物标志物的有用工具。
Serum polyunsaturated fatty acid metabolites as useful tool for screening potential biomarker of colorectal cancer.
作者信息
Zhang Li-Jian, Chen Bin, Zhang Jun-Jie, Li Jian, Yang Qingjing, Zhong Qi-Sheng, Zhan Song, Liu Huwei, Cai Chun
机构信息
Guangdong key laboratory for research and development of nature drugs, Guangdong Medical University, Zhanjiang, Guangdong 524023, China.
Shimadzu Global COE for Application& Technical Development, Guangzhou, Guangdong, 510010, China.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2017 May;120:25-31. doi: 10.1016/j.plefa.2017.04.003. Epub 2017 Apr 28.
The biomarker identification of cancer is benefit for early detection and less invasion. Polyunsaturated fatty acid (PUFA) metabolite as inflammatory mediators can affect progression and treatment of cancer. In this work, the serum was collected from colorectal cancer patients and healthy volunteers, and then we tested the change of serum PUFA metabolites in both of them by ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Of the 158 PUFA and their metabolites, we found that abnormal change of 2, 3-dinor-8-iso-PGF2α, 19-HETE and 12-keto-LTB4 from arachidonic acid were observed in colorectal cancer patients. Meanwhile, 9-HODE and 13-HODE from linoleic acid were significant lower in colorectal cancer patients. Our data suggested that some PUFA metabolites might be used as a potential biomarker of colorectal cancer, which might provide assistance in clinical diagnosis and treatment.
癌症生物标志物的鉴定有助于早期检测且侵袭性较小。多不饱和脂肪酸（PUFA）代谢产物作为炎症介质可影响癌症的进展和治疗。在这项研究中，收集了结直肠癌患者和健康志愿者的血清，然后通过超高效液相色谱串联质谱法（UPLC-MS/MS）检测了两者血清中PUFA代谢产物的变化。在158种PUFA及其代谢产物中，我们发现结直肠癌患者中花生四烯酸的2,3-二去甲-8-异前列腺素F2α、19-羟基二十碳四烯酸和12-酮基白三烯B4出现异常变化。同时，结直肠癌患者中亚油酸的9-羟基十八碳二烯酸和13-羟基十八碳二烯酸显著降低。我们的数据表明，一些PUFA代谢产物可能用作结直肠癌的潜在生物标志物，这可能为临床诊断和治疗提供帮助。
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