Gillman M A, Katzeff I, Vermaak W J, Becker P J, Susani E
S.A. Brain Research Institute, Johannesburg, South Africa.
Horm Metab Res. 1988 Dec;20(12):751-4. doi: 10.1055/s-2007-1010939.
Analgesic concentrations of nitrous oxide were administered to 6 healthy male subjects, and blood samples were assayed for prolactin, ACTH, follicle stimulating hormone, luteinising hormone, growth hormone, cortisol and thyroid hormones. Analgesic nitrous oxide (mean concentration = 48.8%) produced statistically significant elevation of prolactin and depression of cortisol whilst not producing statistically significant changes in the other hormones assayed. The increase in prolactin and decrease in cortisol levels are similar to the hormonal changes associated with administration of opioids in man. We have also confirmed the findings of other workers that cortisol levels may not always be correlated with ACTH levels.
向6名健康男性受试者给予镇痛浓度的一氧化二氮，并对血样进行催乳素、促肾上腺皮质激素、促卵泡激素、促黄体生成素、生长激素、皮质醇和甲状腺激素检测。镇痛浓度的一氧化二氮（平均浓度=48.8%）使催乳素水平在统计学上显著升高，皮质醇水平降低，而对其他检测激素未产生统计学上的显著变化。催乳素增加和皮质醇水平降低与人类使用阿片类药物时的激素变化相似。我们还证实了其他研究人员的发现，即皮质醇水平可能并不总是与促肾上腺皮质激素水平相关。
