Lv Shulan, Xue Xue, Sui Yanxia, Du Juang, Zou Junkai, Sun Chao, Liu Dong, Song Qing, Li Qiling
Department of Obstetrics and Gynecology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Department of Pathology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
Mol Clin Oncol. 2017 May;6(5):661-664. doi: 10.3892/mco.2017.1202. Epub 2017 Mar 22.
Synchronous multiple malignant neoplasms of the female genital tract are rare, particularly in the uterus. We herein present the case of a patient with synchronous cervical squamous epithelial carcinoma and endometrial adenocarcinoma, and discuss the diagnosis, treatment and prognosis. The patient underwent a cervical biopsy and fractional curettage of the endometrium, followed by abdominal staging surgery, including radical hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy. The diagnosis was stage Ib1 cervical cancer and stage Ia endometrial cancer, without lymph node metastases. There has been no recurrence during 1 year of followup. Synchronous genital tract neoplasms are more clinically complex compared with single neoplasms and it is crucial to focus on the differential diagnosis between primary and metastatic tumors during the diagnostic process. The treatment of synchronous genital tract neoplasms also differs significantly from that of single neoplasms, although the prognosis of patients with synchronous gynecological malignancies does not appear to be worse.
女性生殖道同步性多原发性恶性肿瘤较为罕见，尤其是发生于子宫的情况。我们在此报告一例同步发生宫颈鳞状上皮癌和子宫内膜腺癌的患者，并对其诊断、治疗及预后进行讨论。该患者接受了宫颈活检及子宫内膜分段刮宫术，随后进行了腹部分期手术，包括根治性子宫切除术、双侧输卵管卵巢切除术、盆腔及腹主动脉旁淋巴结清扫术。诊断为Ib1期宫颈癌和Ia期子宫内膜癌，无淋巴结转移。随访1年期间未出现复发。与单一肿瘤相比，同步性生殖道肿瘤在临床上更为复杂，在诊断过程中关注原发性肿瘤与转移性肿瘤的鉴别诊断至关重要。同步性生殖道肿瘤的治疗也与单一肿瘤有显著差异，尽管同步性妇科恶性肿瘤患者的预后似乎并不更差。
