Klatt E C
Department of Pathology, University of Southern California School of Medicine, Los Angeles.
J Acquir Immune Defic Syndr (1988). 1988;1(5):459-65.
The clinical and autopsy findings documented in 216 patients with the acquired immune deficiency syndrome (AIDS) are summarized. The respiratory system was most often involved with opportunistic infections and neoplasms diagnostic of AIDS, accounting for one-fourth of all such occurrences. Respiratory failure was the most frequent terminal event, leading to death in two-thirds of AIDS patients. The most common immediate cause of death was Pneumocystis carinii pneumonia, seen in one-third of cases. Autopsy findings modified the clinical impression of the cause of death in 55% of cases. The most common diagnostic disease entity in all organ sites was cytomegalovirus. The total clinical course of AIDS from diagnosis to death averaged 7 months, while the mean terminal hospital course was 20 days, and these courses did not vary substantially over the period of the study. Strategies for diagnosis, therapy, and management in patients with AIDS may be aided by these findings.
总结了216例获得性免疫缺陷综合征（AIDS）患者的临床和尸检结果。呼吸系统最常出现机会性感染和诊断为AIDS的肿瘤，占所有此类病例的四分之一。呼吸衰竭是最常见的终末事件，导致三分之二的AIDS患者死亡。最常见的直接死因是卡氏肺孢子虫肺炎，见于三分之一的病例。尸检结果改变了55%病例的临床死亡原因印象。所有器官部位最常见的诊断疾病实体是巨细胞病毒。AIDS从诊断到死亡的总临床病程平均为7个月，而终末住院病程平均为20天，在研究期间这些病程没有显著变化。这些发现可能有助于AIDS患者的诊断、治疗和管理策略。
