Studinski Rcn, Alexander A, La Russa D
The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.
Med Phys. 2012 Jul;39(7Part4):4638. doi: 10.1118/1.4740181.
The treatment planning software SharePlan is designed to convert dose distributions generated by the TomoTherapy planning station into step-and-shoot IMRT plans deliverable on a c-arm linear accelerator. Five anal canal patients who were planned for TomoTherapy treatments were exported into a SharePlan system and plans were generated for delivery on an Elekta Synergy unit. A total of 80 plans were generated for those five patients, with either seven, nine, eleven or twenty-one gantry angles and different priorities between focusing on matching either the target doses or healthy tissue sparing of the TomoTherapy plan. The plans generated by SharePlan, while often not matching target coverage at prescription, matched well the TomoTherapy coverage at 95% and 105% of the prescription dose. Organ at risk dose, when heavily emphazied in the SharePlan calculations matched or bettered the TomoTherapy dose due to the placement of the beams and the sharper sup-inf fall off of the dose distribution on a linac. For one of the patients, it was possible to produce a better DVH with SharePlan than the original TomoTherapy plan for those reasons. The TomoTherapy plans boasted significantly shorter delivery times than the plans generated with SharePlan.
治疗计划软件SharePlan旨在将TomoTherapy计划站生成的剂量分布转换为可在C形臂直线加速器上实施的静态调强放射治疗（IMRT）计划。5名计划接受TomoTherapy治疗的肛管患者被导入SharePlan系统，并生成了可在医科达Synergy设备上实施的计划。为这5名患者总共生成了80个计划，有7个、9个、11个或21个机架角度，且在侧重于匹配TomoTherapy计划的靶区剂量或保护健康组织方面有不同的优先级。SharePlan生成的计划虽然在处方剂量时往往与靶区覆盖情况不匹配，但在处方剂量的95%和105%时与TomoTherapy的覆盖情况匹配良好。由于直线加速器上射束的放置以及剂量分布在头脚方向上更陡峭的剂量下降，当在SharePlan计算中高度强调危及器官剂量时，其与TomoTherapy剂量相匹配或更优。由于这些原因，对于其中一名患者，使用SharePlan生成的剂量体积直方图（DVH）比原始的TomoTherapy计划更好。TomoTherapy计划的实施时间明显短于用SharePlan生成的计划。
