Nuffield Department of Surgical Sciences, Oxford University, Oxford, UK.
Neurosurgery Department, Oxford University Hospitals, Oxford, UK.
Neuromodulation. 2018 Feb;21(2):126-134. doi: 10.1111/ner.12604. Epub 2017 May 17.
Deep brain stimulation (DBS) is a rapidly developing field of neurosurgery with potential therapeutic applications that are relevant to conditions traditionally viewed as beyond the limits of neurosurgery. Our objective, in this review, is to highlight some of the emerging applications of DBS within three distinct but overlapping spheres, namely trauma, neuropsychiatry, and autonomic physiology.
An extensive literature review was carried out in MEDLINE, to identify relevant studies and review articles describing applications of DBS in the areas of trauma, neuropsychiatry and autonomic neuroscience.
A wide range of applications of DBS in these spheres was identified, some having only been tested in one or two cases, others much better studied.
We have identified various avenues for DBS to be applied for patient benefit in cases relevant to trauma, neuropsychiatry and autonomic neuroscience. Further developments in DBS technology and clinical trial design will enable these novel applications to be effectively and rigorously assessed and utilized most effectively.
深部脑刺激（DBS）是神经外科学领域的一个快速发展分支，具有潜在的治疗应用价值，涉及到传统上被认为超出神经外科学范围的病症。在本综述中，我们的目的是强调 DBS 在三个不同但重叠领域中的一些新兴应用，即创伤、神经精神医学和自主生理。
我们在 MEDLINE 上进行了广泛的文献综述，以确定描述 DBS 在创伤、神经精神医学和自主神经科学领域应用的相关研究和综述文章。
在这些领域中发现了 DBS 的广泛应用，有些仅在一两个病例中进行了测试，有些则得到了更好的研究。
我们已经确定了 DBS 在与创伤、神经精神医学和自主神经科学相关的病例中为患者带来益处的各种途径。DBS 技术和临床试验设计的进一步发展将使这些新的应用能够得到有效和严格的评估，并最有效地利用。
