Katsumata Noriyuki
Department of Molecular Endocrinology, National Research Institute for Child Health and Development 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
Pediatr Endocrinol Rev. 2017 Mar;14 Suppl 1(Suppl 1):209-215. doi: 10.17458/per.vol14.2017.k.standardizationgrowth.
Measurement of the levels of growth hormone (GH) and its related factor insulin-like growth factor I (IGF-I) is essential for the diagnosis and treatment of GH deficiency (GHD) and conditions related to excess GH such as acromegaly and pituitary gigantism. Measurement of GH levels is also used as an indicator of hypothalamic-pituitary function. Because of the marked variability in GH measurements among kits, the Study Committee for GH and Its Related Factors of The Foundation for Growth Science, Japan standardized GH values measured with various commercially available GH assay kits in Japan. The committee also established IGF-I reference values for Japanese subjects of all ages, from childhood to adulthood. Hopefully, international harmonization of GH measurements will be achieved in the future.
生长激素（GH）及其相关因子胰岛素样生长因子I（IGF-I）水平的测定对于生长激素缺乏症（GHD）以及与生长激素过多相关的病症（如肢端肥大症和垂体巨人症）的诊断和治疗至关重要。生长激素水平的测定也用作下丘脑-垂体功能的指标。由于不同试剂盒之间生长激素测量值存在显著差异，日本生长科学基金会生长激素及其相关因子研究委员会对日本市场上各种商用生长激素检测试剂盒所测的生长激素值进行了标准化。该委员会还为日本从儿童到成人的所有年龄段受试者建立了IGF-I参考值。希望未来能实现生长激素测量的国际标准化。
