Li S, Driewer J, Lin C
University Nebraska Medical Center, Omaha, NE.
Med Phys. 2012 Jun;39(6Part14):3769. doi: 10.1118/1.4735354.
TBI treatment delivery MU and patient dose estimation are calculated manually at our institution. This study was to verify the accuracyof MU calculation and dose estimation of bilateral TBI by application of tissue heterogeneity correction.
Twelve TBI patients were simulated from neck to thigh in bilateral TBI position. CT images were imported into the treatment planning system (Philips, Pinnacle3). Treatment dose was prescribed to the midpoint at the level of the umbilicus. Treatment distance was 519 cm. Both 6MV and 23 MV opposite lateral beams delivered 200 cGy to the dose prescription point with a 40 ×40 cm field size and 45o collimator angle. A 1 cm thick spoiler was placed about 15 cm from patient skin. Adaptive convolution superposition with and without heterogeneity correction was used for calculation of MUs and doses at the midpoints of the shoulder, chest, abdomen, and pelvis.
Monitor units calculated with heterogeneity correction were 1.1% and 0.9% smaller on average than those without heterogeneity correction for 6MV and 23MV beams respectively. The maximum deviations of MU were 3.8% and 2.8% smaller. Average percentage differences of point doses with and without heterogeneity corrections were -0.2%, 17.0%, -0.3%, and -2.7% at the levels of shoulder, chest, abdomen, and pelvis for 6MV beam and 0.4%, 11.0%, 0.2%, and -1.7% for 23MV beam. Discrepancy of doses to the points at the shoulder level varied from -6.8% to 8.9% for 6MV beam and from -1.6% to 5.1% for 23MV beam.
Bilateral TBI MU calculation errors caused by ignoring tissue inhomogeneity would be less than 4% and 3% for 6MV and 23 MV beam. Dose estimation is less accurate using 6MV beam and the inaccuracy could be more than 8% for shoulder midpoint and 4% for pelvis midpoint.
在我们机构,全脑全脊髓照射(TBI)治疗的机器跳数(MU)计算和患者剂量估算都是手动完成的。本研究旨在通过应用组织不均匀性校正来验证双侧TBI的MU计算和剂量估算的准确性。
对12例TBI患者进行双侧TBI体位从颈部到大腿的模拟。将CT图像导入治疗计划系统(飞利浦,Pinnacle3)。治疗剂量处方至脐水平的中点。治疗距离为519 cm。6MV和23MV的对侧野均以40×40 cm的射野大小和45°准直器角度向剂量处方点给予200 cGy。在距患者皮肤约15 cm处放置一块1 cm厚的散射体。使用有和没有不均匀性校正的自适应卷积叠加法计算肩部、胸部、腹部和骨盆中点处的MU和剂量。
对于6MV和23MV射野,经不均匀性校正计算的监测单位平均分别比未经校正的小1.1%和0.9%。MU的最大偏差分别小3.8%和2.8%。对于6MV射野,在肩部、胸部、腹部和骨盆水平,有和没有不均匀性校正的点剂量平均百分比差异分别为-0.2%、17.0%、-0.3%和-2.7%;对于23MV射野,分别为0.4%、11.0%、0.2%和-1.7%。6MV射野肩部水平各点的剂量差异在-6.8%至8.9%之间,23MV射野在-1.6%至5.1%之间。
对于6MV和23MV射野,忽略组织不均匀性导致的双侧TBI的MU计算误差分别小于4%和3%。使用6MV射野时剂量估算准确性较低,肩部中点处的不准确性可能超过8%,骨盆中点处超过4%。