Zhang Zhengdong, Dou Kai
RadAmerica LLC MedStar HealthCare.
Med Phys. 2012 Jun;39(6Part13):3756. doi: 10.1118/1.4735292.
To investigate the dosimetric variation by Monte Carlo and experimentally simulating the situation with and without tissue invagination and the potential translation and rotation of the SAVI applicator for partial breast irradiation.
The SAVI applicator with the cavity filled with air and water was merged into a water phantom and the delivered dose was simulated by MCNP monte carlo program. The results verified using an ion chamber and film were compared with a homogenous dose calculation by the treatment planning system. A dose variation from the SAVI translational shift was simulated and measured by moving an ion chamber along with the central axis direction. A dose change from the SAVI rotation was simulated and measured by placing an ion chamber at a fixed point while rotating the SAVI device about the central axis.
The dosimetric variations for the SAVI device were found to be related to the cavity dimension, source arrangement, and dwell times. For the single dwell source placed in the center of the applicator, the maximum difference of the dose with the air cavity at 1cm away from the air-water boundary is about 7% higher than that with water filling in the cavity. But the simulation and measurements with nearly fully loaded multi-sources for the same situation show a difference of less than 3%. The 3% dose variation in average was found from either the 3 mm translation or 3 degree rotation of the SAVI applicator.
The maximum dosimetric effect of an air cavity is 7% off compared with a water filled cavity when a single dwell source position is used in the center of the central catheter. Multiple catheters of the SAVI applicator with a nearly fully loaded dwell source position produce the discrepancy of less than 3% and allow for optimal and conformal dose distribution to a lumpectomy cavity while minimizing the dose to adjacent normal structures.
通过蒙特卡罗方法并通过实验模拟有组织内陷和无组织内陷以及用于部分乳腺照射的SAVI施源器的潜在平移和旋转情况,来研究剂量学变化。
将腔内填充空气和水的SAVI施源器融入水模体中,并通过MCNP蒙特卡罗程序模拟输送剂量。将使用电离室和胶片验证的结果与治疗计划系统的均匀剂量计算结果进行比较。通过沿中心轴方向移动电离室来模拟和测量SAVI平移偏移引起的剂量变化。通过在固定点放置电离室同时使SAVI装置绕中心轴旋转来模拟和测量SAVI旋转引起的剂量变化。
发现SAVI装置的剂量学变化与腔尺寸、源排列和驻留时间有关。对于放置在施源器中心的单驻留源,在距气水边界1cm处,有空腔时的剂量最大差异比腔内填充水时高约7%。但对于相同情况使用几乎满载多源的模拟和测量显示差异小于3%。发现SAVI施源器3mm的平移或3度的旋转平均会导致3%的剂量变化。
当在中心导管中心使用单驻留源位置时,与填充水的腔相比,空气腔的最大剂量学效应相差7%。SAVI施源器的多个导管在几乎满载驻留源位置时产生的差异小于3%,并允许向乳房肿瘤切除腔提供最佳和适形的剂量分布,同时将对相邻正常结构的剂量降至最低。