Dhanesar S, Sahoo N, Taylor M, Song X, Poenisch F, Summers P, Li H, Zhu X R, Gillin M
The University of Texas MD Anderson Cancer Center, Houston, TX.
Med Phys. 2012 Jun;39(6Part3):3613. doi: 10.1118/1.4734667.
To evaluate Zebra multi-layer ionization chamber system for patient treatment field and machine QA for spot scanning proton beams (SSPB) and passive scattering proton beams (PSPB).
Zebra dose measurement system (IBA Dosimetry), consisting of 180 parallel platechambers with 2 mm detector spacing, was used for measuring proton beamdepth dose curves (DDC) for spread out Bragg peaks (SOBP) and single spot pristine Bragg peaks (PBP). The measurements were performed for 100 to 250 MeV PSPB and 89.2 to 221.8 MeV SSPB using the Hitachi ProBeat synchrotron based delivery system. An in-house Matlab based analysis software was used to compare the Zebra measured DDC with those measured by the Markus chamber in a PTW water tank (MC-WT). Several verification plans in the water phantom were created for patient treatment fields using the Eclipse treatment planning system (TPS). The DDC for individual verification fields were measured using the Zebra andcomparisons were made with the TPS calculations.
The dosedifferences between the Zebra and MC-WT measurements in the plateau regions of the DDC are within 2% for various energies of PSPB, but are larger than 2% at the sharp dose distal gradient regions. The values for distal penumbra widths, range and SOBP widths from Zebra and MC-WT measurements agree within 0.5 mm, 1.5 mm, and 2 mm, respectively. The Zebra measured values of the range of the single spots also agreed within 1 mm with their established values from other measurements. The Zebra measured DDC of verification plan of patient treatment fields showed goodagreement with those from the TPS.
Our investigation shows that Zebra can be useful for fast and reasonably accurate measurements of the DDC of pristine and spread-out Bragg peaks of both spot scanning and passive scattering proton beams.
评估斑马多层电离室系统用于患者治疗野以及点扫描质子束(SSPB)和被动散射质子束(PSPB)的机器质量保证。
使用由180个平行板电离室组成、探测器间距为2毫米的斑马剂量测量系统(IBA剂量学),测量扩展布拉格峰(SOBP)和单靶点原始布拉格峰(PBP)的质子束深度剂量曲线(DDC)。使用基于日立ProBeat同步加速器的输送系统,对100至250 MeV的PSPB和89.2至221.8 MeV的SSPB进行测量。使用基于Matlab的内部分析软件,将斑马测量的DDC与PTW水箱中的 Markus电离室测量的DDC进行比较。使用Eclipse治疗计划系统(TPS)在水模体中创建了几个用于患者治疗野的验证计划。使用斑马测量各个验证野的DDC,并与TPS计算结果进行比较。
对于不同能量的PSPB,斑马和MC-WT测量在DDC平台区域的剂量差异在2%以内,但在剂量远端陡峭梯度区域大于2%。斑马和MC-WT测量的远端半影宽度、射程和SOBP宽度值分别在0.5毫米、1.5毫米和2毫米内一致。斑马测量的单靶点射程值与其从其他测量得到的既定值也在1毫米内一致。斑马测量的患者治疗野验证计划的DDC与TPS的结果显示出良好的一致性。
我们的研究表明,斑马可用于快速且合理准确地测量点扫描和被动散射质子束的原始布拉格峰和扩展布拉格峰的DDC。