Schulze D, Ionascu D, Tyagi N
William Beaumont Hospital, Royal Oak, MI.
Med Phys. 2012 Jun;39(6Part20):3849. doi: 10.1118/1.4735712.
To generate hybrid VMAT-IMRT treatment plans by utilizing an IMRT beam-angle-optimality (BAO) search under a commercially available TPS without the aid of custom optimization software or high performance computing.
The high dose modulation provided by IMRT beams can be exploited to improve the quality of VMAT treatments. To achieve this, a VMAT treatment was created where the gantry pauses at predetermined angles to deliver IMRT segments. To determine IMRT BAO, an IMRT plan ('poly-IMRT') was made with many beams (>30) equally spaced around the patient. For practical reasons and to reduce the total time to approximately 1 hour, BAO was approximated by removing one beam out of the set and noting the new objective score. Determining this'score penalty' for each of the beams serves as a proxy for true BAO. The hybrid plan was created by combining the VMAT arc with a user-determined number of top-ranked beams from the poly-IMRT set. The BAO from this approach was compared with a more rigorous method ('VMAT+1'), in which a VMAT plan was optimized with 1 IMRT beam at various angles, allowing a direct determination of objective score versus gantry angle. The overall hybrid planning process was demonstrated by creating separate plans for a SBRT lung patient, with dose normalized to the limiting maximum aorta dose.
Large score penalties from poly-IMRT coincided with large score benefits from VMAT+1, indicating both methods identified the same optimal beams. The VMAT, IMRT, and hybrid plans delivered the prescription dose to 84.3%, 85.6% and 87.7% of the PTV and had homogeneity indices of 1.38, 1.41, and 1.32 respectively. Normal tissue doses were within 0.5%.
The presented method can create hybrid VMAT-IMRT plans which combine delivery efficiency with improved target coverage. The planning process takes about an hour using a standard TPS.
在不借助定制优化软件或高性能计算的情况下,利用商业可用的治疗计划系统(TPS)中的调强放疗(IMRT)射束角度优化(BAO)搜索来生成混合容积调强放疗(VMAT)-IMRT治疗计划。
IMRT射束提供的高剂量调制可用于提高VMAT治疗的质量。为实现这一点,创建了一种VMAT治疗,其中机架在预定角度暂停以递送IMRT射野。为确定IMRT BAO,制作了一个IMRT计划(“多野IMRT”),该计划有许多射束(>30个)围绕患者均匀分布。出于实际原因并将总时间减少到大约1小时,通过从射束集合中移除一个射束并记录新的目标得分来近似BAO。确定每个射束的这种“得分惩罚”可作为真实BAO的替代。通过将VMAT弧与用户确定数量的来自多野IMRT集合的排名靠前的射束相结合来创建混合计划。将这种方法得到的BAO与一种更严格的方法(“VMAT+1”)进行比较,在“VMAT+1”方法中,VMAT计划在不同角度用1个IMRT射束进行优化,从而可以直接确定目标得分与机架角度的关系。通过为一名立体定向体部放疗(SBRT)肺癌患者创建单独的计划来展示整个混合计划过程,剂量归一化为限制最大主动脉剂量。
多野IMRT的大得分惩罚与VMAT+1的大得分益处相吻合,表明两种方法识别出相同的最佳射束。VMAT、IMRT和混合计划分别将处方剂量递送至计划靶体积(PTV)的84.3%、85.6%和87.7%,均匀性指数分别为1.38、1.41和1.32。正常组织剂量在0.5%以内。
所提出的方法可以创建结合了递送效率和改善的靶区覆盖的混合VMAT-IMRT计划。使用标准TPS进行计划过程大约需要1小时。