Mauduit P, Herman G, Dreux C, Rossignol B
Laboratoire de Biochimie des Transports Cellulaires (CNRS UA 1116), Université de Paris-Sud, Orsay, France.
Pathol Biol (Paris). 1988 Oct;36(8 Pt 2):1060-5.
In the present work, we have shown that pentoxifylline (BL 191) and propentofylline (HW 285) penetrate very fast, without storage, in rat parotid and lacrimal gland cells. As phosphodiesterase inhibitor, pentoxifylline induces an increase of cAMP intracellular concentration. Pentoxifylline has a slight but sustained effect on 45Ca efflux and triggers a substantial labeled protein secretion and important glycogenolysis. Taken together, these data could be explained as a synergism between the different regulation routes involving calcium and cAMP.
在本研究中，我们已表明己酮可可碱（BL 191）和丙戊茶碱（HW 285）能非常快速地穿透大鼠腮腺和泪腺细胞，且无蓄积现象。作为磷酸二酯酶抑制剂，己酮可可碱可诱导细胞内cAMP浓度升高。己酮可可碱对45Ca外流有轻微但持续的作用，并引发大量标记蛋白分泌和显著的糖原分解。综合来看，这些数据可解释为涉及钙和cAMP的不同调节途径之间的协同作用。
