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皮下三叉神经区域刺激治疗顽固性面部疼痛

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain.

作者信息

Jakobs Martin, Schuh-Hofer Sigrid, Unterberg Andreas, Ahmadi Rezvan

机构信息

Department of Neurosurgery, University Hospital Heidelberg.

Center for Biomedicine and Medical Technology, University Hospital Mannheim.

出版信息

J Vis Exp. 2017 May 10(123):55408. doi: 10.3791/55408.

Abstract

Chronic or neuropathic trigeminal facial pain can be challenging to treat. Neurosurgical procedures should be applied when conservative treatment fails. Neuromodulation techniques for chronic facial pain include deep brain stimulation and motor cortex stimulation, which are complex to perform. Subcutaneous nerve field stimulation is certified for chronic back pain and is the least invasive form of neuromodulation. We applied this technique to treat chronic and neuropathic trigeminal pain as an individual therapy concept. First, trial stimulation is performed. Subcutaneous leads are placed in the painful trigeminal dermatome under local anesthesia. The leads are connected to an external neurostimulator that applies constant stimulation. Patients undergo a 12 day outpatient trial to assess the effect of the stimulation. Electrodes are removed after the trial. If the patient reports pain reduction of at least 50% in intensity and/or attack frequency, a reduction in medication or increase in quality of life, permanent implantation is scheduled. New electrodes are implanted under general anesthesia and are subcutaneously tunneled to an infraclavicular internal pulse generator. Patients are able to turn stimulation on and off and to increase or decrease the stimulation amplitude as needed. This technique represents a minimal invasive alternative to other more invasive means of neuromodulation for trigeminal pain such as motor cortex stimulation or deep brain stimulation.

摘要

慢性或神经性三叉神经面部疼痛的治疗颇具挑战性。保守治疗无效时应采用神经外科手术。慢性面部疼痛的神经调节技术包括深部脑刺激和运动皮层刺激,这些操作复杂。皮下神经场刺激已被批准用于治疗慢性背痛,是侵入性最小的神经调节形式。我们将此技术作为一种个体化治疗方案应用于慢性和神经性三叉神经痛的治疗。首先,进行试验性刺激。在局部麻醉下将皮下导线置于疼痛的三叉神经皮节区。导线连接到施加持续刺激的外部神经刺激器。患者接受为期12天的门诊试验以评估刺激效果。试验结束后取出电极。如果患者报告疼痛强度和/或发作频率至少降低50%,药物用量减少或生活质量提高,则安排进行永久性植入。在全身麻醉下植入新电极,并通过皮下隧道连接至锁骨下内部脉冲发生器。患者能够根据需要开启或关闭刺激,并增加或降低刺激幅度。与三叉神经痛的其他更具侵入性的神经调节方法(如运动皮层刺激或深部脑刺激)相比,该技术是一种微创替代方法。

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本文引用的文献

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