通过电化学纯化实现了大规模的高官能化二茂铁双亲分子的一般非对映选择性合成。
A general diastereoselective synthesis of highly functionalized ferrocenyl ambiphiles enabled on a large scale by electrochemical purification.
作者信息
Lerayer Emmanuel, Renaut Patrice, Roger Julien, Pirio Nadine, Cattey Hélène, Devillers Charles H, Lucas Dominique, Hierso Jean-Cyrille
机构信息
Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), Université de Bourgogne Franche-Comté (UMR 6302), 9, av. A. Savary, 21078 Dijon, France.
出版信息
Chem Commun (Camb). 2017 May 30;53(44):6017-6020. doi: 10.1039/c7cc02469j.
A general synthesis of highly functionalized ferrocenes, which include (P,B)- and (N,B)-ambiphiles, has been developed at a multigram scale. Diastereoselective stepwise modification of di-tert-butylated ferrocenes included the unprecedented separation of electroactive species. Bulky alkyl groups on ferrocenes ensure planar chirality of ambiphiles and enforce closer proximity of antagonist Lewis functions.
已开发出一种多克规模的高官能化二茂铁的通用合成方法，其中包括（P，B）-和（N，B）-双亲体。二叔丁基二茂铁的非对映选择性逐步修饰包括前所未有的电活性物种分离。二茂铁上的庞大烷基确保了双亲体的平面手性，并使拮抗剂路易斯官能团更紧密地靠近。
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