Zehtabian M, Sina S, Faghihi R, Meigooni A
Comprehensive Cancer Center of Nevada, Las Vegas, NV.
Med Phys. 2012 Jun;39(6Part18):3820. doi: 10.1118/1.4735590.
According to the TG-43 recommendations of American Association of Physicist in Medicine (AAPM), the dosimetry parameters of brachytherapy sources are obtained in a water phantom with full scattering conditions. However, in many actual clinical treatments the source are not surrounded with sufficient tissue in all directions to provide the full scattering condition. HDR brachytherapy of the breast or 125I eye-plaque treatment of the ocular melanoma are among the treatment sites that fits this category. In this project, the impact of insufficient phantom material surrounding the 137Cs, 192Ir, and 103Pd brachytherapy source on their TG43 dosimetric characteristics has been investigated.
In this study, the effect of the insufficient tissue (referred here as missing tissues) around the brachytherapy sources on their TG-43 dosimetric parameters have been investigated using MCNP5 Monte Carlo code. The brachytherapy sources were simulated in different locations inside a cubical water phantom with the dimensions of 303030 cm . The variation of the dosimetric parameters of the three sources (i.e. Î>, g(r), and F(r,θ)) were compared to the values from full scattering conditions (i.e. source at the center of the phantom).
The results of this study indicate the variation of g(r)and 2D anisotropy function of the brachytherapy sources as a function of the missing tissue thickness. These changes increase by decreasing the energy of the photons emitted by the brachytherapy sources. These differences are mainly due to the lack of full scattering condition for the points near the phantom boundary.
Unlike the published data for symmetric, but insufficient phantom material around the source, the impact of asymmetric phantom materials have been evaluated on dosimetric characteristics of the brachytherapy sources.
根据美国医学物理师协会(AAPM)的TG - 43建议,近距离放射治疗源的剂量学参数是在具有完全散射条件的水模体中获得的。然而,在许多实际临床治疗中,放射源在各个方向上并未被足够的组织包围以提供完全散射条件。乳腺的高剂量率近距离放射治疗或眼部黑色素瘤的¹²⁵I眼膜治疗都属于这一类治疗部位。在本项目中,研究了¹³⁷Cs、¹⁹²Ir和¹⁰³Pd近距离放射治疗源周围模体材料不足对其TG43剂量学特征的影响。
在本研究中,使用MCNP5蒙特卡罗代码研究了近距离放射治疗源周围组织不足(此处称为缺失组织)对其TG - 43剂量学参数的影响。将近距离放射治疗源模拟放置在尺寸为30×30×30 cm的立方体水模体内部的不同位置。将这三种源的剂量学参数(即̂、g(r)和F(r,θ))的变化与完全散射条件下(即源位于模体中心)的值进行比较。
本研究结果表明,近距离放射治疗源的g(r)和二维各向异性函数随缺失组织厚度而变化。随着近距离放射治疗源发射光子能量的降低,这些变化会增大。这些差异主要是由于靠近模体边界的点缺乏完全散射条件。
与已发表的关于源周围对称但模体材料不足的数据不同,本研究评估了非对称模体材料对近距离放射治疗源剂量学特征的影响。