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奈多罗米钠对正常受试者气道对吸入辣椒素反应的影响。

Effect of nedocromil sodium on the airway response to inhaled capsaicin in normal subjects.

作者信息

Hansson L, Choudry N B, Fuller R W, Pride N B

机构信息

Department of Clinical Pharmacology, Royal Postgraduate Medical School, London.

出版信息

Thorax. 1988 Nov;43(11):935-6. doi: 10.1136/thx.43.11.935.

DOI:10.1136/thx.43.11.935
PMID:2851881
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC461571/
Abstract

In six normal subjects treatment with 4 mg nedocromil sodium failed to alter the cough and bronchoconstriction induced by inhaled capsaicin. Because nedocromil has previously been shown to inhibit reflex bronchoconstriction provoked by inhaled sulphur dioxide and inhaled bradykinin, the results suggest that inhaled capsaicin acts on different nerve fibres.

摘要

在6名正常受试者中,4毫克奈多罗米钠治疗未能改变吸入辣椒素所诱发的咳嗽和支气管收缩。由于奈多罗米此前已被证明可抑制吸入二氧化硫和吸入缓激肽所诱发的反射性支气管收缩,这些结果表明吸入辣椒素作用于不同的神经纤维。

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本文引用的文献

1
The effect of intravenous sodium cromoglycate on the bronchoconstriction induced by sulphur dioxide inhalation in man.静脉注射色甘酸钠对人体吸入二氧化硫所致支气管收缩的影响。
Clin Sci (Lond). 1985 Feb;68(2):227-32. doi: 10.1042/cs0680227.
2
Bradykinin-induced bronchoconstriction in humans. Mode of action.缓激肽诱导的人类支气管收缩。作用模式。
Am Rev Respir Dis. 1987 Jan;135(1):176-80. doi: 10.1164/arrd.1987.135.1.176.
3
Bronchoconstrictor response to inhaled capsaicin in humans.
J Appl Physiol (1985). 1985 Apr;58(4):1080-4. doi: 10.1152/jappl.1985.58.4.1080.
4
The clinical development of a new agent for the treatment of airway inflammation, nedocromil sodium (Tilade).
Eur J Respir Dis Suppl. 1986;147:120-31.
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Effect of nedocromil sodium on sulphur dioxide induced bronchoconstriction.奈多罗米钠对二氧化硫诱导的支气管收缩的作用。
Thorax. 1987 Jun;42(6):462-5. doi: 10.1136/thx.42.6.462.
6
A new method to determine frequency characteristics of the respiratory system.一种确定呼吸系统频率特性的新方法。
J Appl Physiol. 1976 Jul;41(1):101-6. doi: 10.1152/jappl.1976.41.1.101.