[乙型肝炎感染急性期过程中乙肝病毒相关抗原、受体及抗体的定量和定性研究结果]
[Quantitative and qualitative findings of hepatitis B virus-associated antigens, receptors and antibodies in the course of the acute phase of hepatitis B infection].
作者信息
Gröticke J W, Gerken G, Steinmann J, Arnold W
机构信息
Kliniken der Freien Hansestadt Bremen, Zentralkrankenhaus St.-Jürgen-Strasse.
出版信息
Z Gastroenterol. 1988 Jul;26(7):363-73.
UNLABELLED
Receptors for pHSA may be the links between HBV and hepatocytes. Therefore, we evaluated the correlation between serum binding activity for pHSA during the acute phase of hepatitis B in relation to the decrease of surface antigen concentration.
METHODS
130 sera from 22 patients with acute (HBeAg-positive) hepatitis B were obtained weekly during an average interval of 7 weeks after the onset of the disease. R-pHSA were tested by RIA in 4 titre steps (1:50, 1:500, 1:5000, 1:50,000). HBsAg was analysed quantitatively by RIA according to the standard serum of the Paul-Ehrlich-Institute.
未标记
人血清白蛋白（pHSA）受体可能是乙肝病毒（HBV）与肝细胞之间的联系纽带。因此，我们评估了乙肝急性期血清中pHSA结合活性与表面抗原浓度降低之间的相关性。
方法
从22例急性（HBeAg阳性）乙肝患者中获取130份血清，在疾病发作后平均7周的时间内每周采集一次。用放射免疫分析法（RIA）在4个滴度步骤（1:50、1:500、1:5000、1:50,000）下检测R-pHSA。根据保罗·埃利希研究所的标准血清，用RIA法定量分析HBsAg。
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