Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing University , Nanjing 210093, China.
Org Lett. 2017 Jun 2;19(11):2885-2888. doi: 10.1021/acs.orglett.7b01119. Epub 2017 May 18.
Aromatic heterocycles have been identified as effective directing groups (DGs) in C-H functionalization but can be retained as undesired bulky substituents in the final products. Herein, we report a Co(III)-catalyzed 1-aminoisoquinoline synthesis strategy based on oxadiazole-directed aromatic C-H coupling with alkynes and a subsequent redox-neutral C-N cyclization reaction. This labile N-O bond-based protocol has allowed the toleration of a broad range of functional groups.
芳杂环已被确定为有效的导向基团（DG）在 C-H 功能化中，但在最终产物中可以保留为不需要的大体积取代基。在此，我们报告了一种基于恶二唑导向的芳基 C-H 与炔烃偶联和随后的氧化还原中性 C-N 环化反应的 Co(III)催化 1-氨基异喹啉合成策略。这种基于不稳定 N-O 键的方案允许容忍广泛的官能团。
