Brooks M Alison, Bazarian Jeffrey J, Prichep Leslie S, Dastidar Samanwoy Ghosh, Talavage Thomas M, Barr William
Department of Orthopedics and Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin (Dr Brooks); Department of Emergency Medicine, University of Rochester Medical Center, Rochester, New York (Dr Bazarian); Department of Psychiatry (Dr Prichep) and Departments of Neurology and Psychiatry (Dr Barr), New York University School of Medicine, New York; BrainScope Co, Inc, Bethesda, Maryland (Drs Prichep and Ghosh Dastidar); and Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana (Dr Talavage).
J Head Trauma Rehabil. 2018 Jan/Feb;33(1):1-6. doi: 10.1097/HTR.0000000000000328.
To evaluate the effectiveness of the electroencephalographic (EEG) Brain Function Index (BFI) for characterizing sports-related concussive injury and recovery.
Three hundred fifty-four (354) male contact sport high school and college athletes were prospectively recruited from multiple locations over 6 academic years of play (244 control baseline athletes and 110 athletes with a concussion).
Using 5 to 10 minutes of eyes closed resting EEG collected from frontal and frontotemporal regions, a BFI was computed for all subjects and sessions. Group comparisons were performed to test for the significance of the difference in the BFI score between the controls at baseline and athletes with a concussion at several time points.
There was no significant difference in BFI between athletes with a concussion at baseline (ie, prior to injury) and controls at baseline (P = .4634). Athletes with a concussion, tested within 72 hours of injury, exhibited significant differences in BFI compared with controls (P = .0036). The significant differences in BFI were no longer observed at 45 days following injury (P = .19).
Controls and athletes with a concussion exhibited equivalent BFI scores at preseason baseline. The concussive injury (measured within 72 hours) significantly affected brain function reflected in the BFI in the athletes with a concussion. The BFI of the athletes with a concussion returned to levels seen in controls by day 45, suggesting recovery. The BFI may provide an important objective marker of concussive injury and recovery.
评估脑电图（EEG）脑功能指数（BFI）在表征与运动相关的脑震荡损伤及恢复情况方面的有效性。
在6个学年的比赛期间，从多个地点前瞻性招募了354名从事接触性运动的男性高中和大学运动员（244名对照基线运动员和110名脑震荡运动员）。
从额叶和额颞叶区域采集5至10分钟闭眼静息脑电图，为所有受试者和检查时段计算BFI。进行组间比较，以检验基线时的对照组与脑震荡运动员在几个时间点的BFI得分差异的显著性。
基线时（即受伤前）的脑震荡运动员与基线时的对照组之间的BFI无显著差异（P = 0.4634）。在受伤后72小时内接受测试的脑震荡运动员，其BFI与对照组相比存在显著差异（P = 0.0036）。受伤后45天时，不再观察到BFI的显著差异（P = 0.19）。
在季前赛基线时，对照组和脑震荡运动员的BFI得分相当。脑震荡损伤（在72小时内测量）显著影响了脑震荡运动员BFI所反映的脑功能。脑震荡运动员的BFI在第45天时恢复到对照组的水平，表明已恢复。BFI可能为脑震荡损伤及恢复提供一个重要的客观指标。
