Wang Xianwang, Hu Shujuan, Liu Lei
Laboratory of The Neuronal Network and Brain Diseases Modulation, School of Medicine, Yangtze University, Jingzhou, Hubei 434023, P.R. China.
Institute of Physical Education, Yangtze University, Jingzhou, Hubei 434023, P.R. China.
Oncol Lett. 2017 May;13(5):2867-2872. doi: 10.3892/ol.2017.5851. Epub 2017 Mar 13.
Forkhead box class O 3a (FOXO3a) is a transcription factor that has emerged as being a tumor suppressor and longevity factor. The precise regulation of FOXO3a transactivation of target genes is achieved via post-translational modifications (PTMs) and specific protein-protein interactions. The multiple types of PTMs that FOXO3a undergoes, including phosphorylation, acetylation, methylation and ubiquitination, serve important roles in directing its subcellular localization and transcription activity, which are central to the integration of insulin/growth factor signaling and oxidative/nutrient stress signaling. The present review summarizes the modifications of FOXO3a that occur via phosphorylation and acetylation. In addition, the synergistic effect of multiple phosphorylations on FOXO3a and the crosstalk between phosphorylation and acetylation in the regulation of FOXO3a are discussed. These discussions may highlight potential strategies for the prevention of cancer and aging.
叉头框O类3a（FOXO3a）是一种转录因子，已成为一种肿瘤抑制因子和长寿因子。FOXO3a对靶基因的转录激活通过翻译后修饰（PTM）和特定的蛋白质-蛋白质相互作用来精确调控。FOXO3a经历的多种类型的PTM，包括磷酸化、乙酰化、甲基化和泛素化，在指导其亚细胞定位和转录活性中发挥重要作用，而这些对于胰岛素/生长因子信号和氧化/营养应激信号的整合至关重要。本综述总结了通过磷酸化和乙酰化对FOXO3a进行的修饰。此外，还讨论了多种磷酸化对FOXO3a的协同作用以及在FOXO3a调控中磷酸化和乙酰化之间的相互作用。这些讨论可能会突出预防癌症和衰老的潜在策略。
