Haruki Koichiro, Shiba Hiroaki, Fujiwara Yuki, Furukawa Kenei, Iida Tomonori, Ohkuma Masahisa, Ogawa Masaichi, Ishida Yuichi, Misawa Takeyuki, Yanaga Katsuhiko
Department of Surgery, The Jikei University School of Medicine, Tokyo 105-8461, Japan.
Oncol Lett. 2017 May;13(5):3688-3694. doi: 10.3892/ol.2017.5873. Epub 2017 Mar 17.
Preoperative systemic inflammatory response is associated with a poor long-term prognosis following resection surgery for malignant tumors. Several markers of systemic inflammation have been reported to be associated with the outcome; however, they have not currently been fully investigated. Therefore, the association between preoperative peripheral blood neutrophil count and oncological outcome following hepatic resection for colorectal liver metastasis (CRLM) was retrospectively investigated. The present study comprised 89 patients who had undergone hepatic resection for CRLM between January 2000 and March 2010. The association between preoperative peripheral blood neutrophil count and disease-free survival, in addition to overall survival, was investigated. In multivariate analysis, the presence of neoadjuvant chemotherapy (P=0.015), bilobar distribution (P=0.015) and neutrophil count ≥3,500/µl (P=0.025) were independent and significant predictors of poor disease-free survival, while significant predictors of poor overall survival consisted of >4 lymph node metastases (P=0.001), neo-adjuvant chemotherapy (P=0.003), bilobar distribution (P=0.039) and neutrophil count ≥3,500/µl (P=0.040). Additionally, tumor diameter (P=0.021) and monocyte count (P<0.0001) were observed to be significantly greater in the elevated neutrophil count group. In conclusion, preoperative peripheral blood neutrophil count may be an independent and significant indicator of poor long-term outcomes in patients with CRLM following hepatic resection.
术前全身炎症反应与恶性肿瘤切除术后的长期预后不良相关。已有报道称几种全身炎症标志物与预后相关；然而，目前尚未对其进行充分研究。因此，本研究对术前外周血中性粒细胞计数与结直肠癌肝转移（CRLM）肝切除术后肿瘤学结局之间的关联进行了回顾性调查。本研究纳入了2000年1月至2010年3月期间接受CRLM肝切除术的89例患者。研究了术前外周血中性粒细胞计数与无病生存期以及总生存期之间的关联。在多因素分析中，新辅助化疗的使用（P = 0.015）、双叶分布（P = 0.015）和中性粒细胞计数≥3500/µl（P = 0.025）是无病生存期不良的独立且显著的预测因素，而总生存期不良的显著预测因素包括>4个淋巴结转移（P = 0.001）、新辅助化疗（P = 0.003）、双叶分布（P = 0.039）和中性粒细胞计数≥3500/µl（P = 0.040）。此外，中性粒细胞计数升高组的肿瘤直径（P = 0.021）和单核细胞计数（P<0.0001）显著更高。总之，术前外周血中性粒细胞计数可能是CRLM患者肝切除术后长期预后不良的独立且显著指标。
