Department of Biomedical Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY. United States.
Department of Pharmaceutical Technology, School of Pharmacy, University of Santiago de Compostela. Spain.
Curr Pharm Des. 2017;23(24):3507-3514. doi: 10.2174/1381612823666170516145309.
Incorporating therapeutic molecules into biomorphic ceramics for in situ drug release can be used to generate novel systems for tissue regeneration. These systems couple the complex hierarchical porous structures of biomorphic ceramics with the therapeutic activity of drugs. There are a large number of natural precursors available to be used as templates to obtain biomorphic silicon carbide ceramics. Additionally, different drug loading techniques can be used for these systems. The high versatility in structures and drugs allows the selection of the right structure-drug fit in each case according to the tissue needs. This paper reviews the utility of biomorphic ceramics for tissue engineering as well as their use for local drug release.
将治疗分子纳入仿生陶瓷中进行原位药物释放，可用于生成组织再生的新型系统。这些系统将仿生陶瓷的复杂分级多孔结构与药物的治疗活性结合在一起。有大量的天然前体可用作模板来获得仿生碳化硅陶瓷。此外，还可以为这些系统使用不同的药物加载技术。结构和药物的高度通用性允许根据组织需求为每种情况选择合适的结构-药物匹配。本文综述了仿生陶瓷在组织工程中的应用及其用于局部药物释放的用途。
