Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models.
作者信息
Su Xiaomin, Fischer D Luke, Li Xin, Bankiewicz Krystof, Sortwell Caryl E, Federoff Howard J
机构信息
Department of Neuroscience, Georgetown University Medical Center, Washington DC 20057, USA.
Translational Science and Molecular Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI 48824, USA.
出版信息
Mol Ther. 2017 Oct 4;25(10):2231-2235. doi: 10.1016/j.ymthe.2017.04.018. Epub 2017 May 15.
Abstract
摘要
相似文献
1
Alpha-Synuclein mRNA Is Not Increased in Sporadic PD and Alpha-Synuclein Accumulation Does Not Block GDNF Signaling in Parkinson's Disease and Disease Models.α-突触核蛋白mRNA在散发性帕金森病中并未增加，且在帕金森病及疾病模型中α-突触核蛋白的积累并不阻断胶质细胞源性神经营养因子信号传导。
Mol Ther. 2017 Oct 4;25(10):2231-2235. doi: 10.1016/j.ymthe.2017.04.018. Epub 2017 May 15.
2
GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease.GDNF 未能在帕金森病的大鼠 α-突触核蛋白模型中发挥神经保护作用。
Brain. 2011 Aug;134(Pt 8):2302-11. doi: 10.1093/brain/awr149. Epub 2011 Jun 28.
3
Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease.在帕金森病基因大鼠模型中，通过慢病毒将胶质细胞源性神经营养因子（GDNF）递送至黑质并不能预防神经退行性变。
Neurobiol Dis. 2004 Nov;17(2):283-9. doi: 10.1016/j.nbd.2004.06.008.
4
Alteration in alpha-synuclein mRNA expression in Parkinson's disease.帕金森病中α-突触核蛋白mRNA表达的改变。
Mov Disord. 2004 Feb;19(2):162-70. doi: 10.1002/mds.10683.
5
Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice.替米沙坦通过调节 C57BL/6J 小鼠中α-突触核蛋白和神经营养因子（BDNF 和 GDNF）的表达来减轻 MPTP 诱导的多巴胺能变性和运动功能障碍。
Neuropharmacology. 2013 Oct;73:98-110. doi: 10.1016/j.neuropharm.2013.05.025. Epub 2013 Jun 6.
6
α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.α-突触核蛋白诱导的 Nurr1 下调破坏黑质多巴胺神经元中的 GDNF 信号。
Sci Transl Med. 2012 Dec 5;4(163):163ra156. doi: 10.1126/scitranslmed.3004676.
7
Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients.散发性帕金森病患者中α-突触核蛋白mRNA的水平。
Mov Disord. 2006 Oct;21(10):1703-8. doi: 10.1002/mds.21007.
8
6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo.6-羟多巴胺在体内诱导大鼠黑质纹状体系统中 GDF5 和 GDNF mRNA 表达的明显改变。
Neurosci Lett. 2014 Feb 21;561:176-81. doi: 10.1016/j.neulet.2013.12.046. Epub 2013 Dec 25.
9
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.脑内 α-突触核蛋白在多系统萎缩、帕金森病和进行性核上性麻痹中的蓄积：一项比较性研究。
Brain. 2010 Jan;133(Pt 1):172-88. doi: 10.1093/brain/awp282. Epub 2009 Nov 10.
10
α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat model.α-突触核蛋白疫苗接种可预防与调节性 T 细胞募集相关的纹状体中类似帕金森病的病理包涵体的积累，在大鼠模型中。
J Neuropathol Exp Neurol. 2013 Jul;72(7):624-45. doi: 10.1097/NEN.0b013e31829768d2.
引用本文的文献
1
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils.用预形成原纤维诱导的大鼠早期突触核蛋白病的转录组分析。
NPJ Parkinsons Dis. 2024 Jan 3;10(1):7. doi: 10.1038/s41531-023-00620-y.
2
Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity.利用预形成纤维模型区分α-突触核蛋白包涵体与黑质纹状体变性相关免疫原性。
Neurobiol Dis. 2022 Sep;171:105804. doi: 10.1016/j.nbd.2022.105804. Epub 2022 Jun 25.
3
Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons.用原纤维种子在原代培养的小鼠多巴胺能神经元中模拟 α-突触核蛋白聚集和神经退行性变。
Cells. 2022 May 13;11(10):1640. doi: 10.3390/cells11101640.
4
Neurotrophins as Therapeutic Agents for Parkinson's Disease; New Chances From Focused Ultrasound?神经营养因子作为帕金森病的治疗药物；聚焦超声带来新机遇？
Front Neurosci. 2022 Mar 25;16:846681. doi: 10.3389/fnins.2022.846681. eCollection 2022.
5
Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic.激活胶质细胞源性神经营养因子/RET信号通路是成功治疗帕金森病的答案吗？从培养皿到临床的数据讨论。
Neural Regen Res. 2022 Jul;17(7):1462-1467. doi: 10.4103/1673-5374.327330.
6
Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy.纹状体多巴胺能神经元作为基于 GDNF 的缺血性中风治疗的潜在靶点。
Turk J Med Sci. 2022 Feb;52(1):248-257. doi: 10.3906/sag-2108-268. Epub 2022 Feb 22.
7
Mechanistic Insight from Preclinical Models of Parkinson's Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy.帕金森病临床前模型的机制研究有助于重新调整 GDNF 治疗的临床试验努力。
Int J Mol Sci. 2021 Oct 28;22(21):11702. doi: 10.3390/ijms222111702.
8
Activators of alpha synuclein expression identified by reporter cell line-based high throughput drug screen.基于报告细胞系高通量药物筛选鉴定的α-突触核蛋白表达激活剂。
Sci Rep. 2021 Oct 6;11(1):19857. doi: 10.1038/s41598-021-98841-9.
9
Growth differentiation factor 5: a neurotrophic factor with neuroprotective potential in Parkinson's disease.生长分化因子5：一种在帕金森病中具有神经保护潜力的神经营养因子。
Neural Regen Res. 2022 Jan;17(1):38-44. doi: 10.4103/1673-5374.314290.
10
GDNF Therapy: Can We Make It Work?GDNF 疗法：我们能让它发挥作用吗？
J Parkinsons Dis. 2021;11(3):1019-1022. doi: 10.3233/JPD-212706.
本文引用的文献
1
Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease.在帕金森病患者中存在独特的肠内磷酸化α-突触核蛋白聚集和基因表达谱。
Acta Neuropathol Commun. 2017 Jan 5;5(1):1. doi: 10.1186/s40478-016-0408-2.
2
Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism.帕金森病小鼠模型中α-突触核蛋白的进行性聚集及含路易小体神经元的选择性变性。
Cell Rep. 2015 Mar 3;10(8):1252-60. doi: 10.1016/j.celrep.2015.01.060. Epub 2015 Feb 26.
3
Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain.重组腺相关病毒2/5介导的基因转移在老年大鼠中脑有所减少。
Neurobiol Aging. 2015 Feb;36(2):1110-20. doi: 10.1016/j.neurobiolaging.2014.07.047. Epub 2014 Oct 13.
4
GDNF signaling implemented by GM1 ganglioside; failure in Parkinson's disease and GM1-deficient murine model.由GM1神经节苷脂实现的胶质细胞源性神经营养因子信号传导；在帕金森病和GM1缺陷小鼠模型中的失败。
Exp Neurol. 2015 Jan;263:177-89. doi: 10.1016/j.expneurol.2014.10.010. Epub 2014 Oct 23.
5
Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system.腺相关病毒2/5介导的人野生型α-突触核蛋白在大鼠黑质纹状体系统中过表达的形态学和行为学影响
PLoS One. 2013 Nov 27;8(11):e81426. doi: 10.1371/journal.pone.0081426. eCollection 2013.
6
Disentangling the relationship between lewy bodies and nigral neuronal loss in Parkinson's disease.厘清帕金森病中路易小体与黑质神经元丢失之间的关系。
J Parkinsons Dis. 2011;1(3):277-86. doi: 10.3233/JPD-2011-11046.
7
α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons.α-突触核蛋白诱导的 Nurr1 下调破坏黑质多巴胺神经元中的 GDNF 信号。
Sci Transl Med. 2012 Dec 5;4(163):163ra156. doi: 10.1126/scitranslmed.3004676.
8
Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons.AAV 介导的α-突触核蛋白过表达诱导中脑多巴胺神经元进行性神经退行性变和行为改变。
Neurobiol Dis. 2012 Mar;45(3):939-53. doi: 10.1016/j.nbd.2011.12.013. Epub 2011 Dec 11.
9
GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson's disease.GDNF 未能在帕金森病的大鼠 α-突触核蛋白模型中发挥神经保护作用。
Brain. 2011 Aug;134(Pt 8):2302-11. doi: 10.1093/brain/awr149. Epub 2011 Jun 28.
10
α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study.帕金森病患者脑脊液中α-突触核蛋白和tau 浓度：一项队列研究。
Lancet Neurol. 2011 Mar;10(3):230-40. doi: 10.1016/S1474-4422(11)70014-X.
Zotero 插件