Singh Anusha, Bora Puran, Krishna Amitabh
Department of Zoology, Banaras Hindu University, Varanasi 221005, India.
Department of Ophthalmology, Jones Eye Institute, Pat & Willard Walker Eye Research Center, 4301 West Markham, University of Arkansas for Medical Sciences, Arkansas, 72205, USA.
Biochem Biophys Res Commun. 2017 Jul 1;488(3):509-515. doi: 10.1016/j.bbrc.2017.05.076. Epub 2017 May 15.
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder of reproductive age females, leading to infertility. Despite extensive research, the exact pathophysiology and treatment are lacking. The aim of the current study was to evaluate the direct role of adiponectin either alone or together with luteinizing hormone (LH) on sex hormone synthesis and changes in insulin receptor (IR) in the ovary of dehydroepiandrosterone (DHEA)-treated PCOS-mice. Immunohistochemical study showed decreased expression of adiponectin receptor (AdipoR1) in PCOS-ovary which correlated with increased synthesis of androgen and decreased expression of IR. The treatment with adiponectin with or without LH to PCOS-ovary in vitro caused significant decline in androgen synthesis and increase in IR. This study showed the direct role of adiponectin in ameliorating hyperandrogenism and reducing IR in the ovary of PCOS-mice. Thus adiponectin treatment may be a novel therapeutic strategy for combating PCOS.
多囊卵巢综合征（PCOS）是育龄期女性常见的内分泌和代谢紊乱疾病，可导致不孕。尽管进行了广泛研究，但仍缺乏确切的病理生理学和治疗方法。本研究的目的是评估脂联素单独或与黄体生成素（LH）共同对脱氢表雄酮（DHEA）处理的PCOS小鼠卵巢中性激素合成及胰岛素受体（IR）变化的直接作用。免疫组织化学研究显示，PCOS卵巢中脂联素受体（AdipoR1）表达降低，这与雄激素合成增加和IR表达降低相关。在体外对PCOS卵巢给予脂联素（无论有无LH）治疗，可使雄激素合成显著下降，IR增加。本研究表明脂联素在改善PCOS小鼠卵巢高雄激素血症和降低IR方面具有直接作用。因此，脂联素治疗可能是对抗PCOS的一种新的治疗策略。
