Hong-Yuan Mou, School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China.
World J Gastroenterol. 2017 Apr 28;23(16):2957-2963. doi: 10.3748/wjg.v23.i16.2957.
To verify the value of Gutuo Jiejiu decoction in improving the survival of patients with severe alcoholic hepatitis (SAH).
We performed a retrospective cohort study in consecutive patients diagnosed with SAH at the Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine. The traditional Chinese medicine formula Gutuo Jiejiu decoction was employed as an exposure factor. Patients from the Teaching Hospital of Chengdu University of Traditional Chinese Medicine who had been treated with Gutuo Jiejiu decoction + prednisone were assigned to an observation group, and patients from Shuguang Hospital, Shanghai University of Traditional Chinese Medicine who had been treated with prednisone alone were selected as a control group. A retrospective analysis was performed by comparing age, alcohol intake, and clinical parameters of liver injury before and after treatment. Additionally, the 3- and 12-mo survival rates and the occurrence of complications were analyzed.
One hundred and twenty-eight eligible patients were selected from 175 cases with SAH, of which 68 were assigned to the observation group and the other 60 to the control group. No significant difference was found in the patients' baseline characteristics ( > 0.05). However, significant improvements of 90-d survival rate [56/68 (82.4%) 27/60 (45.0%), = 0.0000] and 365-d survival rate [48/68 (70.6%) 13/60 (21.7%), = 00000] were observed in the observation group after treatment. After the first 3 mo of treatment, more improvements in the clinical parameters and scoring systems related to liver injury occurred in the observation group than in the control group ( < 0.05). After treatment for 12 mo, the differences in the clinical parameters and scoring systems related to liver injury between the two groups were more significant ( < 0.05). No significant differences in complications and adverse effects were found between the two groups.
Gutuo Jiejiu decoction could improve the survival rates and clinical parameters of liver injury in patients with SAH, and may represent a new option for treating SAH.
验证谷脱解毒汤提高重症酒精性肝炎（SAH）患者生存率的价值。
对连续在成都中医药大学附属医院和上海中医药大学曙光医院诊断为 SAH 的患者进行回顾性队列研究。采用中药谷脱解毒汤作为暴露因素。在成都中医药大学附属医院接受谷脱解毒汤+泼尼松治疗的患者被分配到观察组，在上海中医药大学曙光医院接受单纯泼尼松治疗的患者被选为对照组。通过比较治疗前后的年龄、饮酒量和肝损伤的临床参数，进行回顾性分析。此外，还分析了 3 个月和 12 个月的生存率和并发症的发生情况。
从 175 例 SAH 患者中筛选出 128 例符合条件的患者，其中 68 例分配到观察组，60 例分配到对照组。患者的基线特征无显著差异（>0.05）。然而，治疗后观察组 90 天生存率[56/68（82.4%）比 27/60（45.0%），=0.0000]和 365 天生存率[48/68（70.6%）比 13/60（21.7%），=0.0000]显著提高。治疗后 3 个月，观察组在与肝损伤相关的临床参数和评分系统方面的改善更为显著，优于对照组（<0.05）。治疗 12 个月后，两组与肝损伤相关的临床参数和评分系统的差异更为显著（<0.05）。两组在并发症和不良反应方面无显著差异。
谷脱解毒汤可提高 SAH 患者的生存率和肝损伤的临床参数，可能为治疗 SAH 提供新的选择。
