鸡脑中不依赖钠离子的L-天冬氨酸结合位点
Na+-independent L-aspartate binding sites in chick brain.
作者信息
Voukelatou G, Kouvelas E D
机构信息
Department of Physiology, School of Medicine, University of Patras, Greece.
出版信息
Neurochem Res. 1988 Sep;13(9):879-85. doi: 10.1007/BF00970757.
PMID:2852308
Abstract
- One binding component with a Kd value of 200 x 10(-9) M and half-life of the ligand binding component of 30 min was found. 2. Chloride ions produced a significant increase of L-[3H]aspartate and L-[3H]glutamate binding. 3. L-Glutamate, L-ibotenate, L-quisqualate, and DL-homocysteic acid were potent inhibitors of L-[3H]aspartate binding. 4. In all brain regions major increases of binding were observed during the third week of the in ovo period of life.
摘要
- 发现一种结合成分，其解离常数（Kd）值为200×10⁻⁹ M，配体结合成分的半衰期为30分钟。2. 氯离子使L-[³H]天冬氨酸和L-[³H]谷氨酸的结合显著增加。3. L-谷氨酸、L-鹅膏蕈氨酸、L-quisqualate和DL-高半胱氨酸是L-[³H]天冬氨酸结合的强效抑制剂。4. 在胚胎期生命的第三周，所有脑区均观察到结合的主要增加。
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